Tsuyoshi Miyazaki

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STUDY DESIGN This study was aimed at investigating changes in the dorsal horn of the lumbar cord induced by mechanical compression using an in vivo model. OBJECTIVE To determine the effect of axonal flow disturbance in the dorsal horns induced by nerve root compression. SUMMARY OF BACKGROUND DATA Few studies have looked at changes of synapses within the(More)
A critical issue in today's super-aging society is the need to reduce the burden of family care while continuing to make our medical institutions supportive. A rapidly emerging, major health concern is the debilitating effect of muscle weakness and atrophy from aging, termed sarcopenia; however, the molecular basis of this condition is not well understood.(More)
After HRP injection into the geniohyoid muscle labeled neurons were found in the ventral part of the hypoglossal nucleus, extending in the rostral two-thirds (about) of this nucleus. After HRP injection in to the thyrohyoid muscle, the labeled neurons were identified in the lateral part of the caudal one-third (about) of the hypoglossal nucleus and in the(More)
The function of the nonreceptor tyrosine kinase c-Src as a plasma membrane-associated molecular effector of a variety of extracellular stimuli is well known. Here, we show that c-Src is also present within mitochondria, where it phosphorylates cytochrome c oxidase (Cox). Deleting the c-src gene reduces Cox activity, and this inhibitory effect is restored by(More)
To examine the role of mitogen-activated protein kinase and nuclear factor kappa B (NF-kappaB) pathways on osteoclast survival and activation, we constructed adenovirus vectors carrying various mutants of signaling molecules: dominant negative Ras (Ras(DN)), constitutively active MEK1 (MEK(CA)), dominant negative IkappaB kinase 2 (IKK(DN)), and(More)
After HRp injection into the posterior cricoarytenoid (PCA), the thyroarytenoid (TA), the lateral cricoarytenoid (LCA) and the interarytenoid (IA) muscles, labeled neurons were identified in the nucleus ambiguus ipsilaterally. The motoneurons for the cricothyroid muscle (CT) were found ipsilaterally in the retrofacial and ambiguus nuclei. The labeled cell(More)
INTRODUCTION Mesenchymal stem cells (MSCs) can differentiate into various connective tissue cells. Several techniques have been used for the clinical application of MSCs in articular cartilage repair; however, there are many issues associated with the selection of the scaffold material, including its ability to support cell viability and differentiation and(More)
Following HRP (Horseradish Peroxidase) injections to cricothyroid muscle, recurrent laryngeal nerve and the vagal nerve at the level of nodose ganglion, labeled motoneurons were found to show a characteristic distribution in the brain stem of the monkey. Cricothyroid motoneurons extended from a level caudal to the facial nucleus to a level caudal to the(More)
To examine the role of mitogen-activated protein kinase and nuclear factor kappa B (NF-␬ B) pathways on osteoclast survival and activation, we constructed adenovirus vectors carrying various mutants of signaling molecules: dominant negative Ras (Ras DN), constitutively active MEK1 (MEK CA), dominant negative I ␬ B kinase 2 (IKK DN), and constitutively(More)
Antibodies against acetylcholine receptors (AChRs) cause pathogenicity in myasthenia gravis (MG) patients through complement pathway-mediated destruction of postsynaptic membranes at neuromuscular junctions (NMJs). However, antibodies against muscle-specific kinase (MuSK), which constitute a major subclass of antibodies found in MG patients, do not activate(More)