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It is widely accepted that most general anaesthetic agents depress the central nervous system (CNS) by potentiation or activation of the GABAA receptor-mediated Cl– conductance. These agents also(More)
Anesthesia and surgery disturb sleep. Disturbed sleep adversely affects postoperative complications involving the cardiovascular system, diabetes, and infection. General anesthetics share neuronal(More)
Dexmedetomidine is a highly selective alpha(2)-agonist and reduces norepinephrine release from several neuronal tissues. However, supraclinical concentrations of dexmedetomidine have been reported to(More)