Tsutomu Kimura

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Simultaneous observations of aerosols, gases, and precipitation chemistry were carried out at the cloud base level and the surface during the fall of 1979, the winter of 1979-1980 and the summer of 1980. With due regard to the effects of the evaporation of precipitation particles and the absorption of gases, the relative importance of in-cloud scavenging(More)
A series of GN8 derivatives were synthesized from various diamines, carboxylic acid derivatives, and nitrogen nucleophiles, and their antiprion activity was tested in TSE-infected mouse neuronal cells. We found that two ethylenediamine units, hydrophobic substituents on the nitrogen atoms, and the diphenylmethane scaffold were essential structural features(More)
2,3,4,9-Tetrahydro-9-[2-hydroxy-3-(1-piperidinyl)propyl]-6-methyl-1H-carbazol-1-one (GJP14) is a novel anti-prion compound that we previously discovered by in silico screening and cellular assay. In this study, a variety of GJP14 derivatives were prepared using pyrrole derivatives, (haloalkyl)oxiranes, and amines, and their anti-prion activity was evaluated(More)
Prion diseases, also known as transmissible spongiform encephalopathies, are fatal neurodegenerative disorders for which no effective curative or prophylactic method has been established. Recently, we discovered a novel antiprion compound, GN8. Administration of GN8 was found to prolong the survival of prion-infected mice. The aim of this study was to(More)
To develop a rat T-cell-dependent antibody response (TDAR) model evaluating both primary and secondary antibody responses, keyhole limpet hemocyanin (KLH) was used to immunize rats twice during a 14-day course of study, a pattern closely linked to that of a short-term general toxicity study. Female rats of four representative strains (e.g., Sprague-Dawley,(More)
P-Chiral alkyl or aryl phenylphosphinoselenoic chlorides were obtained by reacting PhPCl(2) with Grignard reagents and elemental selenium. P-Chiral dialkyl chlorides were also obtained by treating PCl(3) with two different Grignard reagents and elemental selenium. The structure of the chloride was determined by X-ray molecular structure analysis. P-Chiral(More)
A radiolabeled PET! A (11) C-labeled derivative of N,N'-(methylenedi-4,1-phenylene)bis[2-(1-pyrrolidinyl) acetamide] (GN8), an antiprion agent currently under development, was synthesized by palladium-catalyzed rapid methylation of aryltributylstannane and assessed for brain penetration and organ distribution in rats by positron emission tomography (PET).