Hironori Yokoyama18
Masaaki Hori12
Keiichi Ishigame10
Jiro Kasahara9
18Hironori Yokoyama
12Masaaki Hori
10Keiichi Ishigame
9Jiro Kasahara
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The biochemical and cellular changes that occur following treatment with MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine) are remarkably similar to that seen in idiopathic Parkinson's disease. In this study, we investigated the time course changes of NF-kappaB (Nuclear factor kappa B) p65 protein and apoptosis in the substantia nigra after MPTP treatment(More)
  • Hideyuki Yoshioka, Toru Horikoshi, Shigeki Aoki, Masaaki Hori, Keiichi Ishigame, Mikito Uchida +3 others
  • 2008
OBJECTIVE We prospectively investigated the predictive value of diffusion tensor tractography for motor functional outcome in a case series of patients with intracerebral hemorrhage. METHODS Diffusion tensor tractography was performed in 17 patients with intracerebral hemorrhage (putamen, nine patients; thalamus, seven patients; combined, one patient)(More)
BACKGROUND AND PURPOSE T1-weighted spin-echo imaging has been widely used to study anatomic detail and abnormalities of the brain; however, the image contrast of this technique is often poor, especially at low field strengths. We tested a new pulse sequence, T1-weighted fluid-attenuated inversion recovery (FLAIR), which provides good contrast between(More)
Relatively little is known about normal prefrontal lobe development. We used three-dimensional magnetic resonance imaging (MRI)-based brain volumetry to characterize developmental changes in prefrontal lobe volumes in infants and children. Prefrontal volumes were determined in 30 subjects aged 5 months to 18 years (221 months) and 3 adults aged 28-39 years(More)
This study examined the ways in which gait patterns and physiological rhythms such as those of muscle activity (tibialis anterior (TA) and biceps femoris (BF)) and cardiac activity are affected by the fatigue induced by prolonged free walking. Twelve normal subjects who walked for 3 h at their preferred pace were divided into two groups according to whether(More)
We investigated the age-related alterations of astorocyte, oligodendrocyte and microglia in the mouse hippocampal CA1 sector under the same conditions using immunohistochemistry. Glial fibrillary acidic protein (GFAP), 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) and isolectin B(4) immunoreactivity was measured in 2-, 8-, 18-, 40-42- and(More)
Dopaminergic neurons are selectively vulnerable to oxidative stress and inflammatory attack. The neuronal cell loss in the substantia nigra is associated with a glial response composed markedly of activated microglia and, to a lesser extent, of reactive astrocytes although these glial responses may be the source of neurotrophic factors and can protect(More)
The biochemical, behavioral and immunohistochemical manifestations were investigated in mice subjected to four experimental schedules with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) hydrochloride treatment. The mice were treated intraperitoneally with MPTP (20 mg/kg in saline) four times a day at 2-h intervals showed severe and persistent(More)
  • Keizo Takao, Koichi Tanda, Kenji Nakamura, Jiro Kasahara, Kazuki Nakao, Motoya Katsuki +10 others
  • 2010
Calcium-calmodulin dependent protein kinase IV (CaMKIV) is a protein kinase that activates the transcription factor CREB, the cyclic AMP-response element binding protein. CREB is a key transcription factor in synaptic plasticity and memory consolidation. To elucidate the behavioral effects of CaMKIV deficiency, we subjected CaMKIV knockout (CaMKIV KO) mice(More)
We investigated mainly immunohistochemical changes of nestin (a marker of neuroepithelial stem cells) and Ki-67 (a marker of proliferating cells) proteins related to ageing in the mouse hippocampus and subventricular zone (SVZ) using young adult (8 weeks old) and middle-aged (40 weeks old) mice. In the present study, no significant changes in neurons and(More)