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Integrin-mediated Activation of MAP Kinase Is Independent of FAK: Evidence for Dual Integrin Signaling Pathways in Fibroblasts

• Tsung Hau Lin, Andrew E. Aplin, +5 authors R. L. Juliano
• The Journal of cell biology
• 1997

Integrin-mediated cell adhesion causes activation of MAP kinases and increased tyrosine phosphorylation of focal adhesion kinase (FAK). Autophosphorylation of FAK leads to the binding of SH2-domain… (More)

Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation.

• Min Shi, Tsung Hau Lin, Kenneth C Appell, Leslie J Berg
• Immunity
• 2008

Differentiation of naive CD4+ T cells into T helper type 1 (Th1) effector cells requires both T cell receptor (TCR) signaling and cytokines such as interleukin-12 and interferon gamma (IFN-gamma).… (More)

pSTAT3: a target biomarker to study the pharmacology of the anti-IL-21R antibody ATR-107 in human whole blood

• Ming Zhu, Susan Pleasic-Williams, Tsung Hau Lin, David A. Wunderlich, John B Cheng, Jaime L. Masferrer
• Journal of Translational Medicine
• 2012

IL-21 has been shown to play an important role in autoimmune diseases. ATR-107 is an antibody which directly targets the IL-21 receptor (IL-21R). To aid the clinical development of ATR-107, there is… (More)

Identification and characterization of small-molecule inhibitors of Tie2 kinase.

• Jinqi Liu, Tsung Hau Lin, +8 authors Maria L Webb
• FEBS letters
• 2008

Angiopoietins and Tie2 receptor were recently identified as an endothelial cell-specific ligand-receptor system that is critical for vascular development and postnatal pathologic angiogenesis by… (More)

Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.

• Michael L. Vazquez, Neelu Kaila, +32 authors Ray Unwalla
• Journal of medicinal chemistry
• 2018

Janus kinases (JAKs) are intracellular tyrosine kinases that mediate the signaling of numerous cytokines and growth factors involved in the regulation of immunity, inflammation, and hematopoiesis. As… (More)

2-Benzimidazolyl-9-(chroman-4-yl)-purinone derivatives as JAK3 inhibitors.

• Andrew G Cole, Adolph C Bohnstedt, +20 authors Maria L Webb
• Bioorganic & medicinal chemistry letters
• 2009

A novel class of Janus tyrosine kinase 3 (JAK3) inhibitors based on a 2-benzimidazoylpurinone core structure is described. Through substitution of the benzimidazoyl moiety and optimization of the N-9… (More)

Successful screening of large encoded combinatorial libraries leading to the discovery of novel p38 MAP kinase inhibitors.

• Axel Metzger, David J. Diller, Tsung Hau Lin, Ian R. Henderson, Maria L Webb
• Combinatorial chemistry & high throughput…
• 2006

Screening of more than 2 million compounds comprising 41 distinct encoded combinatorial libraries revealed a novel structural class of p38 mitogen-activated protein (MAP) kinase inhibitors. The… (More)

The discovery of novel chemotypes of p38 kinase inhibitors.

• David J. Diller, Tsung Hau Lin, Axel Metzger
• Current topics in medicinal chemistry
• 2005

In the late 1970s and the early 1980s the initial p38 chemotype, the triaryl imidazoles, was discovered as an off-target effect during the development of cyclooxygenase and 5-lipoxygenase inhibitors… (More)

Discovery and characterization of triaminotriazine aniline amides as highly selective p38 kinase inhibitors.

• Tsung Hau Lin, Axel Metzger, +6 authors Maria L Webb
• The Journal of pharmacology and experimental…
• 2006

The p38 mitogen-activated protein (MAP) kinases are a family of serine/threonine protein kinases that play important roles in cellular responses to inflammation and external stress. Inhibitors of the… (More)

The discovery of orally active triaminotriazine aniline amides as inhibitors of p38 MAP kinase.

• Katerina Leftheris, Gulzar Saeed Ahmed, +35 authors Maria L Webb
• Journal of medicinal chemistry
• 2004

A new structural class of triaminotriazine aniline amides possessing potent p38 enzyme activity has been discovered. The initial hit (compound 1a) was identified through screening the Pharmacopeia… (More)

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