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We used a variety of statistical measures to identify the point process that describes the maintained discharge of retinal ganglion cells (RGC's) and neurons in the lateral geniculate nucleus (LGN) of the cat. These measures are based on both interevent intervals and event counts and include the interevent-interval histogram, rescaled range analysis, the(More)
We report that neuronal spike trains can exhibit high, stimulus-dependent temporal precision even while the trial-to-trial response variability, measured in several traditional ways, remains substantially independent of the stimulus. We show that retinal ganglion cells and neurons in the lateral geniculate nucleus (LGN) of cats in vivo display both these(More)
We employ a number of statistical measures to characterize neural discharge activity in cat retinal ganglion cells (RGCs) and in their target lateral geniculate nucleus (LGN) neurons under various stimulus conditions, and we develop a new measure to examine correlations in fractal activity between spike-train pairs. In the absence of stimulation (i.e., in(More)
PURPOSE Anomalies in the pulsatility of the eye have been associated with many types of ocular pathology. Estimation of ocular pulsatility is usually obtained by measuring the variation in the intraocular pressure using tonometry-based instruments. In this work, the authors present and demonstrate the applicability of a novel and noninvasive Fourier-domain(More)
Today's ultrafast lasers operate at the physical limits of optical materials to reach extreme performances. Amplification of single-cycle laser pulses with their corresponding octave-spanning spectra still remains a formidable challenge since the universal dilemma of gain narrowing sets limits for both real level pumped amplifiers as well as parametric(More)
Recent studies have shown that ocular hemodynamics and eye tissue biomechanical properties play an important role in the pathophysiology of glaucoma. Nevertheless, better, non-invasive methods to assess these characteristics in vivo are essential for a thorough understanding of degenerative mechanisms. Here, we propose to measure ocular tissue movements(More)
Frequency conversion by means of Kerr nonlinearity is one of the most common and exploited nonlinear optical processes in the UV, visible, IR, and mid-IR spectral regions. Here we show that wave mixing of an optical field and a terahertz wave can be achieved in diamond, resulting in the frequency conversion of the terahertz radiation either by sum- or(More)
PURPOSE To measure the pulsatile movement of neuroretinal tissue at the optic nerve head synchronous with the cardiac cycle. METHODS We used a noninvasive imaging device based on Fourier domain low-coherence interferometry to measure the pulsatile movements of the optic nerve head, peripapillary retina, and cornea with submicron accuracy along a line(More)
We investigate the spatially and temporally resolved four-wave mixing of terahertz (THz) fields and optical pulses in large-bandgap dielectrics, such as diamond. We show that it is possible to perform beam profiling and space-time resolved mapping of THz fields by encoding the spatial information into an optical signal, which can then be recorded by a(More)
Time-domain spectroscopy using coherent millimeter and sub-millimeter radiation (also known as terahertz radiation) is rapidly expanding its application, owing greatly to the remarkable advances in generating and detecting such radiation. However, many current techniques for coherent terahertz detection have limited dynamic range, thus making it difficult(More)