Tsunemitsu Soeda

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The liver and exocrine pancreas share a common structure, with functioning units (hepatic plates and pancreatic acini) connected to the ductal tree. Here we show that Sox9 is expressed throughout the biliary and pancreatic ductal epithelia, which are connected to the intestinal stem-cell zone. Cre-based lineage tracing showed that adult intestinal cells,(More)
Sox9 is a direct transcriptional activator of cartilage-specific extracellular matrix genes and has essential roles in chondrogenesis. Mutations in or around the SOX9 gene cause campomelic dysplasia or Pierre Robin Sequence. However, Sox9-dependent transcriptional control in chondrogenesis remains largely unknown. Here we identify Wwp2 as a direct target of(More)
Sox9 expression defines cell progenitors in a variety of tissues during mouse embryogenesis. To establish a genetic tool for cell-lineage tracing and gene-function analysis, we generated mice in which the CreERT2 gene was targeted to the endogenous mouse Sox9 locus. In Sox9(CreERT2/+) ;R26R embryos, tamoxifen activated Cre recombinase exclusively in(More)
BACKGROUND The authors reported a mutation, P1158S, of the human skeletal muscle sodium channel gene (SCN4A) in a family with cold-induced hypokalemic periodic paralysis (hypoKPP) and myotonia. OBJECTIVE To identify mechanisms of temperature dependency in this channelopathy. METHODS Using the amphotericin B perforated patch clamp method, sodium currents(More)
STUDY DESIGN Retrospective comparative study. OBJECTIVE To examine the incidence and characteristics of key spinopelvic parameters that are correlated with sacral fracture development after lumbosacral fusion. SUMMARY OF BACKGROUND DATA Sacral fracture is a possible complication of instrumented lumbosacral fusion and this has recently been documented in(More)
STUDY DESIGN Single-center retrospective study. OBJECTIVE We examined the risk factors for cage retropulsion after posterior lumbar interbody fusion (PLIF) performed for patients with degenerative lumbar spinal diseases. SUMMARY OF BACKGROUND DATA Although PLIF is a widely accepted procedure, problems remain regarding perioperative and postoperative(More)
STUDY DESIGN A retrospective comparative study. OBJECTIVE The purpose of this study was to compare the stability and outcomes of a hybrid technique with those of a 3-vertebra corpectomy in the management of 4-segment cervical myelopathy. SUMMARY OF BACKGROUND DATA Patients with primarily ventral disease and loss of cervical lordosis are considered good(More)
STUDY DESIGN Single-center retrospective study. OBJECTIVE We examined whether extremely wide and asymmetric anterior decompression causes postoperative C5 palsy. SUMMARY OF BACKGROUND DATA Postoperative C5 palsy is a complication of cervical decompression surgery. We hypothesized that C5 palsy may be caused by nerve root impairment through extremely(More)
BACKGROUND Impaction bone grafting allows restoration of the acetabular bone stock in revision hip arthroplasty. The success of this technique depends largely on achieving adequate initial stability of the component. To obtain well-compacted, well-graded allograft aggregates, we developed an ex vivo compaction device to apply it in revision total hip(More)