Learn More
By cutting the brachial plexus at a few levels on the side stimulated, it was verified that the first far-field component of SEPs with forepaw reference recording is generated in the brachial plexus in the cat. Incidentally, a reversal of the polarity of the earliest portion of the first component was observed with abduction of the upper arm to a high(More)
Transcription factor, cAMP response element-binding protein (CREB), which is phosphorylated by cAMP-dependent kinase via an increase in cAMP, and regulates gene transcription by binding to the cAMP response element (CRE) on target genes. We examined age-dependent alterations in the DNA-binding activity of CREB in rat brain regions, and the effects of(More)
Studies on the clinical course of familial ALS suggest that the duration of illness is relatively consistent for each mutation but variable among the different mutations. The authors analyzed the relative amount of mutant compared with normal SOD1 protein in the erythrocytes from 29 patients with ALS with 22 different mutations. Turnover of mutant SOD1(More)
Short latency SEPs recorded in hand-scalp, ear-scalp and upper neck-scalp leads with stimulation of the median nerve were examined in 27 normal subjects and in 11 selected patients with unilateral complete loss of position sense in order to provide information concerning the generator sources of these potentials. Evidences obtained from both normal subjects(More)
The concept that action potentials recorded by fluid electrodes may be generated at the point of the entrance to and the exit from the partition and that the action potential recorded by the fluid electrodes with a number of partitions between them may be equal to the algebraic sum of the action potentials recorded by the electrodes adjacent to each(More)
The initial positive component of the scalp-recorded somatosensory evoked potential to median nerve stimulation was studied in 12 patients with sensory impairment for all modalities of the unilateral extremities due to lesions at or above or below the thalamic level, taking the potentials obtained from eight normal subjects as control. In normal subjects,(More)
OBJECTIVE After microvascular decompression to treat hemifacial spasm (HFS), resolution of the HFS is often gradual. We carefully investigated the course of the gradual resolution of HFS and examined the differences between patients with and without postoperative HFS. METHODS One hundred seventy-five patients with HFS were monitored, for observation of 1)(More)
In both cats and dogs propidium iodide (PI) which fluoresces red was injected into the rectal striated sphincter muscle and bisbenzimide (BB) which fluoresces blue into the vesical striated sphincter muscle of the same animal. In both cats and dogs neurons labeled with PI were concentrated dorsomedially in Onuf's nucleus, while those labeled with BB were(More)
Transgenic mice carrying familial amyotrophic lateral sclerosis (FALS)-linked mutant Cu/Zn superoxide dismutase (SOD1) genes such as G93A (G93A-mice) and G85R (G85R-mice) genes develop limb paresis. Introduction of human wild type SOD1 (hWT-SOD1) gene, which does not cause motor impairment by itself, into different FALS mice resulted in different effects on(More)
The effects of bromocriptine in patients with Parkinson's disease manifesting various problems in levodopa therapy were tested in a double-blind manner with the collaboration of 59 institutions. The slow and low principle was in part adopted. Either bromocriptine or placebo was added to levodopa. Twenty-nine % of the bromocriptine-treated patients (n =(More)