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Mutations in Surf1, a human gene involved in the assembly of cytochrome c oxidase (COX), cause Leigh syndrome, the most common infantile mitochondrial encephalopathy, characterized by a specific COX deficiency. We report the generation and characterization of functional knockdown (KD) lines for Surf1 in Drosophila. KD was produced by post-transcriptional(More)
The complete genome sequencing has opened the way to the investigation of the transcriptional activity of thousands of genes (i.e the transcriptome) through DNA microarrays. In parallel to these technological developments high-resolution two-dimensional gels combined with sensitive mass spectrometry and other new methods provide the possibility of studying(More)
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