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OBJECTIVE To demonstrate the feasibility of using a computerized system to detect the onset of a seizure and, in response, initiate Vagus nerve stimulation (VNS) in patients with medically refractory epilepsy. METHODS We designed and built a non-invasive, computerized system that automatically initiates VNS following the real-time detection of a(More)
BACKGROUND Malformations of cortical development (MCD) are increasingly recognized as an important cause of epilepsy and developmental delay. MCD encompass a wide spectrum of disorders with various underlying genetic etiologies and clinical manifestations. High resolution imaging has dramatically improved our recognition of MCD. REVIEW SUMMARY This review(More)
The objective of this study was the development of a remote monitoring system to monitor and detect simple motor seizures. Using accelerometer-based kinematic sensors, data were gathered from subjects undergoing medication titration at the Beth Israel Deaconess Medical Center. Over the course of the study, subjects repeatedly performed a predefined set of(More)
PURPOSE To examine the efficacy and safety profile of antiepileptic repetitive transcranial magnetic stimulation (rTMS) for refractory status epilepticus (RSE) in the intensive care unit (ICU) setting. In addition, hypothetical concerns about electrical interference of rTMS with ICU equipment have been previously raised. METHODS We describe two cases of(More)
http://dx.doi.org/10.1016/j.clinph.2014.12.004 1388-2457/ 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. ⇑ Corresponding author at: 330 Brookline Ave, West/Baker 5, Boston, MA 02215, USA. Tel.: +1 617 632 8934; fax: +1 617 632 8931. E-mail addresses: svanhaer@gmail.com (S. VanHaerents),(More)
PURPOSE We have previously demonstrated that it is common for alerting stimuli to induce electrographic seizures and other periodic or rhythmic patterns in the critically ill; however, only 1 of the first 33 patients we reported with this phenomenon had a detectable clinical correlate. METHODS Review of charts and video EEG findings in critically ill(More)
Epileptic seizures usually consist of stereotyped motor movements in association with characteristic changes in the electroencephalogram (EEG). Accurate recognition and quantification of seizures in patients with epilepsy is essential for diagnosis, selection of treatment and assessing the effects of therapy. In this paper, we present some preliminary(More)
OPINION STATEMENT Status epilepticus is a neurologic emergency with significant potential morbidity and even mortality. It should be diagnosed and treated as quickly as possible, with concurrent rapid identification of the underlying cause. Nonconvulsive status epilepticus can be difficult to diagnose due to its protean manifestations, so a high index of(More)
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