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Human protein reference database as a discovery resource for proteomics
The Human Protein Reference Database (http://www.hprd.org) is a web-based resource based on open source technologies for protein information about several aspects of human proteins including protein-protein interactions, post-translational modifications, enzyme-substrate relationships and disease associations. Expand
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K63‐specific deubiquitination by two JAMM/MPN+ complexes: BRISC‐associated Brcc36 and proteasomal Poh1
An unusual deubiquitinating (DUB) activity exists in HeLa cell extracts that is highly specific for cleaving K63‐linked but not K48‐linked polyubiquitin chains. The activity is insensitive to bothExpand
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Biomarker Discovery from Pancreatic Cancer Secretome Using a Differential Proteomic Approach*S
Quantitative proteomics can be used as a screening tool for identification of differentially expressed proteins as potential biomarkers for cancers. Candidate biomarkers from such studies canExpand
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Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event
In a previous study, we showed that the inositol pyrophosphate diphosphoinositol pentakisphosphate (IP7) physiologically phosphorylates mammalian and yeast proteins. We now report that this phosphateExpand
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Comprehensive proteomic analysis of human pancreatic juice.
Proteomic technologies provide an excellent means for analysis of body fluids for cataloging protein constituents and identifying biomarkers for early detection of cancers. The biomarkers currentlyExpand
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Cloning and characterization of PAK5, a novel member of mammalianp21-activated kinase-II subfamily that is predominantly expressed in brain
The p21-activated kinase (PAK) family of protein kinases has recently attracted considerable attention as an effector of Rho family of small G proteins and as an upstream regulator of MAPK signallingExpand
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A Proteomic Analysis of Human Bile*
We have carried out a comprehensive characterization of human bile to define the bile proteome. Our approach involved fractionation of bile by one-dimensional gel electrophoresis and lectin affinityExpand
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A Mass Spectrometry-based Proteomic Approach for Identification of Serine/Threonine-phosphorylated Proteins by Enrichment with Phospho-specific Antibodies
Although proteins phosphorylated on tyrosine residues can be enriched by immunoprecipitation with anti-phosphotyrosine antibodies, it has been difficult to identify proteins that are phosphorylatedExpand
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Mac‐2‐binding protein is a diagnostic marker for biliary tract carcinoma
Biliary tract carcinoma is a deadly disease, accounting for nearly 4500 malignancy‐related deaths each year in the United States. Early detection has the potential to improve survival for patientsExpand
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K 63-specific deubiquitination by two JAMM / MPN þ complexes : BRISC-associated Brcc 36 and proteasomal Poh 1
An unusual deubiquitinating (DUB) activity exists in HeLa cell extracts that is highly specific for cleaving K63-linked but not K48-linked polyubiquitin chains. The activity is insensitive to bothExpand
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