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Properties of the human erythrocyte glucose transport protein are determined by cellular context.
Human erythrocyte hexose transfer is mediated by the glucose transport protein GLUT1 and is characterized by a complexity that is unexplained by available hypotheses for carrier-mediated sugarExpand
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Determinants of ligand binding affinity and cooperativity at the GLUT1 endofacial site.
Cytochalasin B (CB) and forskolin (FSK) inhibit GLUT1-mediated sugar transport in red cells by binding at or close to the GLUT1 endofacial sugar binding site. Paradoxically, very low concentrationsExpand
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Peptide-Based Selective Inhibitors of Matrix Metalloproteinase-Mediated Activities
The matrix metalloproteinases (MMPs) exhibit a broad array of activities, some catalytic and some non-catalytic in nature. An overall lack of selectivity has rendered small molecule, active siteExpand
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Peptide from the C-terminal domain of tissue inhibitor of matrix metalloproteinases-2 (TIMP-2) inhibits membrane activation of matrix metalloproteinase-2 (MMP-2).
Cellular activation of latent matrix metalloproteinase-2 (proMMP-2) requires formation of a cell membrane-associated activation complex that involves specific binding between the hemopexin domain ofExpand
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Exosite Interactions Impact Matrix Metalloproteinase Collagen Specificities*
Members of the matrix metalloproteinase (MMP) family selectively cleave collagens in vivo. However, the substrate structural determinants that facilitate interaction with specific MMPs are not wellExpand
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Identification of collagen binding domain residues that govern catalytic activities of matrix metalloproteinase-2 (MMP-2).
An innovative approach to enhance the selectivity of matrix metalloproteinase (MMP) inhibitors comprises targeting these inhibitors to catalytically required substrate binding sites (exosites) thatExpand
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Second Generation Triple-Helical Peptide Inhibitors of Matrix Metalloproteinases.
The design of selective matrix metalloproteinase (MMP) inhibitors that also possess favorable solubility properties has proved to be especially challenging. A prior approach using collagen-modelExpand
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GLUT1 Structure Function; Context, Ligand Cooperativity, and Mutagenesis Studies: A Dissertation
Carrier mediated nutrient import is vital for cell and tissue homeostasis. Structural insights of carrier mediated transport, particularly the human glucose transporter GLUT1, are essential forExpand