Trisha M. Stan

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In the central nervous system, ageing results in a precipitous decline in adult neural stem/progenitor cells and neurogenesis, with concomitant impairments in cognitive functions. Interestingly, such impairments can be ameliorated through systemic perturbations such as exercise. Here, using heterochronic parabiosis we show that blood-borne factors present(More)
Importance Alzheimer disease (AD) pathology starts long before clinical symptoms manifest, and there is no therapy to treat, delay, or prevent the disease. A shared blood circulation between 2 mice (aka parabiosis) or repeated injections of young blood plasma (plasma from 2- to 3-month-old mice) into old mice has revealed benefits of young plasma on(More)
The sharing of circulation between two animals using a surgical procedure known as parabiosis has created a wealth of information towards our understanding of physiology, most recently in the neuroscience arena. The systemic milieu is a complex reservoir of tissues, immune cells, and circulating molecules that is surprisingly not well understood in terms of(More)
As you suggested, we present now the data most central to the conclusions in the main part of the paper and streamlined the supplement to leave out unnecessary data, which do not directly contribute to the main message. Consequently, in the second part of the paper, we removed data concerning CCL2 and focused instead on CCL11 for which we have strong in(More)
Complex regional pain syndrome (CRPS) is a painful, disabling, chronic condition whose etiology remains poorly understood. The recent suggestion that immunological mechanisms may underlie CRPS provides an entirely novel framework in which to study the condition and consider new approaches to treatment. Using a murine fracture/cast model of CRPS, we studied(More)
BACKGROUND The aetiology and pathogenesis of non-genetic forms of frontotemporal dementia (FTD) is unknown and even with the genetic forms of FTD, pathogenesis remains elusive. Given the association between systemic inflammation and other neurodegenerative processes, links between autoimmunity and FTD need to be explored. OBJECTIVE To describe the(More)
Philipp A. Jaeger1,§,#,*, Trisha M. Stan1,#, Eva Czirr1, Markus Britschgi1,†, Daniela Berdnik1, Ruo-Pan Huang2, Bradley F. Boeve3, Adam L. Boxer4, Nicole Finch5, Gabriela K. Fragiadakis6, Neill R. Graff-Radford5, Ruochun Huang4, Hudson Johns1, Anna Karydas4, David S. Knopman3, Michael Leipold6,7, Holden Maecker6,7, Zachary Miller4, Ronald C. Petersen5, Rosa(More)
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