Trish A Morgan

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Transforming growth factor-β1 (TGF-β) is a growth factor that has multiple functions including potent inhibition of cell growth. TGF-β signals by binding to its cell surface serine/threonine kinase receptors, which in turn phosphorylate downstream signal transducers, Smad2 and Smad3. Phosphorylated Smad2 and Smad3, together with Smad4, enter the nucleus and(More)
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