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Down-regulatory mechanism of mammea E/BB from Mammea siamensis seed extract on Wilms’ Tumor 1 expression in K562 cells
TLDR
Mammea E/BB had pleotropic effects on kinase signaling pathways, resulting in inhibition of leukemia cell proliferation and down-regulation of WT1 expression in K562 cell line. Expand
Costunolide and parthenolide from Champi Sirindhorn (Magnolia sirindhorniae) inhibit leukemic cell proliferation in K562 and molt-4 cell lines
TLDR
The active compounds from M. sirindhorniae were identified as promising sources for bioactive compounds for further applications in traditional medicine and reduced WT1 protein levels in a time- and dose-dependent manner. Expand
Sesquiterpene lactones from the leaves of Magnolia sirindhorniae
TLDR
Five sesquiterpene lactones, costunolide (1), santamarine (2), reynosin (3), parthenolide(4), and lipiferolides (5), were isolated from the leaves of Magnolia sirindhorniae by analysis of spectroscopic data and comparison with those reported in the literature. Expand
Inhibitory effects of costunolide and parthenolide from Champi Sirindhorn (Magnolia sirindhorniae) on FLT3 protein expression in EoL-1 leukemic cells
Background: FLT3 (Fms-like tyrosine kinase 3) belongs to the class III receptor tyrosine kinase that is involved in hematopoietic progenitor cell proliferation. It is a prognostic marker for acuteExpand