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Dicer1 and miR-219 Are Required for Normal Oligodendrocyte Differentiation and Myelination
To investigate the role of microRNAs in regulating oligodendrocyte (OL) differentiation and myelination, we utilized transgenic mice in which microRNA processing was disrupted in OL precursor cellsExpand
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An AICD-based functional screen to identify APP metabolism regulators
BackgroundA central event in Alzheimer's disease (AD) is the regulated intramembraneous proteolysis of the β-amyloid precursor protein (APP), to generate the β-amyloid (Aβ) peptide and the APPExpand
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Abstract B23: Crucial deubiquitinases in cancer cell survival
Deubiquitinases (DUBs) are enzymes that proteolytically cleave ubiquitin from substrates. Substrates include oncogenes, tumor suppressors and polyubiquitinated proteins marked for degradation by theExpand