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Three-Dimensional Atlas System for Mouse and Rat Brain Imaging Data
We present a method for reconstructing 3-D brain atlases from digital 2-D atlas diagrams, and exemplify 3- D atlas-based analysis of PET and MRI data. Expand
Evaluation of the kappa-opioid receptor-selective tracer [11C]GR103545 in awake rhesus macaques
PurposeThe recent development in radiosynthesis of the 11C-carbamate function increases the potential of [11C]GR103545, which for the last decade has been regarded as promising for imaging theExpand
Striatal dopamine deficits predict reductions in striatal functional connectivity in major depression: a concurrent 11C-raclopride positron emission tomography and functional magnetic resonance
Major depressive disorder (MDD) is characterized by the altered integration of reward histories and reduced responding of the striatum. We have posited that this reduced striatal activation in MDD isExpand
Metabolic plasticity in the supraspinal pain modulating circuitry after noxious stimulus-induced spinal cord LTP
Abstract It has been suggested that spinal cord long‐term potentiation (LTP) may contribute to hypersensitivity and hyperalgesia. We have investigated if noxious stimulus‐induced spinal cord LTPExpand
Anatomical standardization of small animal brain FDG-PET images using synthetic functional template: Experimental comparison with anatomical template
Anatomical standardization (also called spatial normalization) of positron emission tomography (PET) small animal brain images is required to make statistical comparisons across individuals. Expand
Biodistribution and Radiation Dosimetry of 18F-FTC-146 in Humans
The purpose of this study was to assess safety, biodistribution, and radiation dosimetry in humans for the highly selective σ-1 receptor PET agentExpand
Radiosynthesis and First-In-Human PET/MRI Evaluation with Clinical-Grade [18F]FTC-146
PurposeSigma-1 receptors (S1Rs) play an important role in many neurological disorders. Simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) with S1R radioligands mayExpand
Spinal long‐term potentiation is associated with reduced opioid neurotransmission in the rat brain
Introduction:  Neuronal events leading to development of long‐term potentiation (LTP) in the nociceptive pathways may be a cellular mechanism underlying hyperalgesia. In the present study, we examineExpand
Morphine reduced perceived anger from neutral and implicit emotional expressions
The μ-opioid system modulates responses to pain and psychosocial stress and mediates non-social and social reward. In humans, the μ-opioid agonist morphine can increase overt attention to theExpand
Brain penetrant small molecule (18)F-GnRH receptor (GnRH-R) antagonists: Synthesis and preliminary positron emission tomography imaging in rats.
INTRODUCTION The gonadotropin releasing hormone receptor (GnRH-R) has a well-described neuroendocrine function in the anterior pituitary. However, little is known about its function in the centralExpand