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Three different ways of shifting the pCa/tension curve on the pCa axis have been studied and related to changes in the rate constants of the cross-bridge cycle. The curve midpoint shifts to higher pCa's when the substrate (Mg-ATP) is reduced from 5 to 0.25 mM, when the phosphate concentration is reduced from 7.5 mM to 0, and when the ionic strength is(More)
and D. de Ruiter. 2005. Assessing diet in savanna herbivores using stable carbon isotope ratios of faeces. In African savannas, browse-based resources (C 3 plants) are isotopically distinct from grasses (C 4 plants). The carbon isotopic composition of the basic plant diet is recorded in animal tissues. Mammal faeces are a readily accessible, non-invasive,(More)
Thin-walled aerospace structures can be idealised as dimensionally reduced shell models. These models can be analysed in a fraction of the time required for a full 3D model yet still provide remarkably accurate results. The disadvantages of this approach are the time taken to derive the idealised model, though this is offset by the ease and rapidity of(More)
BACKGROUND AND AIMS The resurgence of malaria, particularly in the developing world, is considerable and exacerbated by the development of single-gene multi-drug resistances to chemicals such as chloroquinone. Drug therapies, as recommended by the World Health Organization, now include the use of antimalarial compounds derived from Artemisia annua--in(More)
In this paper, a novel approach to automatically sub-divide a complex geometry and apply an efficient mesh is presented. Following the identification and removal of thin-sheet regions from an arbitrary solid using the thick/thin decomposition approach developed by Robinson et al. [1], the technique here employs shape metrics generated using local sizing(More)
The creation of idealised, dimensionally reduced meshes for preliminary design and optimisation remains a time-consuming, manual task. A dimensionally reduced model is ideal for assessing design changes through modification of element properties without the need to create a new geometry or mesh. In this paper, a novel approach for automating the creation of(More)
Three different ways of shifting the pCa/tension curve on the pCa axis have been studied and related to changes in the rate constants of the cross-bridge cycle. The curve midpoint shifts to higher pCa's wheel the substrate (Mg-ATP) is reduced from 5 to 0.25 mM, when the phosphate concentration is reduced from 7.5 mM to 0, and when the ionic strength is(More)
This paper describes an automatic method for generating analysis models to be meshed with finite elements of more than one dimension, known as mixed dimensional models. Mixed dimensional models offer much reduced analysis times, while not compromising simulation accuracy to the same extent as fully dimensionally reduced models composed of 2D elements(More)