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OBJECTIVES Recent clinical trials suggest an LDL-independent superiority of intensive statin therapy in reducing target vessel revascularization and peri-procedural myocardial infarctions in patients who undergo percutaneous coronary interventions (PCI). While animal studies demonstrate that statins mobilize endothelial progenitor cells (EPCs) which can(More)
BACKGROUND In patients undergoing primary percutaneous coronary intervention (PPCI) ticagrelor is superior to clopidogrel in reducing cardiovascular events. This study sought to evaluate the effect of clopidogrel pretreatment on the pharmacodynamics of ticagrelor in patients undergoing PPCI. METHODS We measured platelet reactivity using the VerifyNow(More)
D espite ongoing advances in percutaneous revasculariza-tion, coronary artery bypass grafting (CABG) continues to be performed in a large number of patients, with Ͼ400 000 operations reported in 2007 in the United States alone. 1 Although arterial conduits are generally preferred, saphenous vein grafts (SVGs) continue to be used regularly. First described(More)
Progenitor cell therapy is hindered in patients with diabetes mellitus (DM) due to cellular senescence. Glycogen synthase kinase-3β (GSK3β) activity is increased in DM, potentially exacerbating impaired cell-based therapies. Thus, we aimed to determine if and how GSK3β inhibitors (GSKi) can improve therapeutic efficacy of endothelial progenitor cells (EPC)(More)
Coronary revascularization remains the standard treatment for obstructive coronary artery disease and can be accomplished by either percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery. Considerable advances have rendered PCI the most common form of revascularization and improved clinical outcomes. However, numerous challenges to(More)
BACKGROUND The adoption of the transradial (TR) approach over the traditional transfemoral (TF) approach has been hampered by concerns of increased radiation exposure-a subject of considerable debate within the field. We performed a patient-level, multi-center analysis to definitively address the impact of TR access on radiation exposure. METHODS AND(More)
D espite ongoing advances in percutaneous revasculariza-tion, coronary artery bypass grafting (CABG) continues to be performed in a large number of patients, with Ͼ400 000 operations reported in 2007 in the United States alone. 1 Although arterial conduits are generally preferred, saphenous vein grafts (SVGs) continue to be used regularly. First described(More)
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