• Publications
  • Influence
Selective Effects of Acute Serotonin and Catecholamine Depletion on Memory in Healthy Women
There is converging evidence that brain serotonin and dopamine may selectively modulate learning and memory in humans. However, this has not been directly demonstrated. In the current study, we usedExpand
Human Melatonin Suppression by Light is Intensity Dependent
Five intensities of artificial light were examined for the effect on nocturnal melatonin concentrations. Maximum suppression of melatonin following 1 hr of light at midnight was 71%, 67%, 44%, 38%,Expand
Comparative bioavailability of orally and vaginally administered progesterone.
OBJECTIVE To study the pharmacokinetics of progesterone (P) in healthy premenopausal female volunteers to compare the bioavailability of orally or vaginally administered hormone. DESIGN SubjectsExpand
A double-blind placebo-controlled randomised pilot study of nocturnal melatonin in tracheostomised patients.
BACKGROUND AND AIM Patients in the intensive care unit often suffer from lack of sleep at night. We hypothesised that nocturnal melatonin may increase observed nocturnal sleep in tracheostomisedExpand
Melatonin Sensitivity to Dim White Light in Affective Disorders
Both dim and bright light has been shown to suppress the nocturnal secretion of the pineal hormone melatonin. Early reports suggests that an abnormal response to light occurs in patients with bipolarExpand
Olanzapine excretion in human breast milk: estimation of infant exposure.
Newer antipsychotic drugs offer significant clinical advantages for the treatment of psychosis. In particular for the treatment of postpartum disorders newer agents may be suited due to theirExpand
Dopamine D1 receptor binding in the striatum of patients with obsessive-compulsive disorder.
BACKGROUND Obsessive-compulsive disorder (OCD) is a chronic anxiety disorder of unknown aetiology. Psychopharmacological studies have suggested a role for the neurotransmitter serotonin howeverExpand
Quantal melatonin suppression by exposure to low intensity light in man.
Plasma melatonin concentrations were examined following three relatively low intensities of artificial light. Six normal, healthy control subjects were all exposed to (a) 200 lux, (b) 400 lux and (c)Expand
Measurement of tricyclic antidepressants. Part I. A review of methodology.
tribution, and excretion of AT, NT, IMI, or DM1. The assay was usually by spectrophotometry or simple chemical analyses, some of which involved separation of parent drug from its metabolites byExpand
Behavioural studies of spatial working memory dysfunction in schizophrenia: A quantitative literature review
Cognitive impairments in schizophrenia have been recognized as a prominent feature of the illness. Research is now focusing on determining a relationship between neurocognitive impairments, andExpand