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Chronic wound infections are typically polymicrobial; however, most in vivo studies have focused on monospecies infections. This project was designed to develop an in vivo, polymicrobial, biofilm-related, infected wound model in order to study multispecies biofilm dynamics and in relation to wound chronicity. Multispecies biofilms consisting of both Gram(More)
  • T Dalton
  • 1979
1. 5-Hydroxytryptamine (5-HT) stimulates active sodium transport and decreases the passive mucosal to serosal chloride permeability across frog skin. The relative importance of the different regions of the 5-HT molecule in the mediation of these responses has been studied using a range of structurally related compounds. 2. Substitution in the ethyl amine(More)
Human nonadherent peripheral blood mononuclear cells (PBMC) isolated from nonimmunized donors were preincubated for 18 h in medium alone or medium containing the lymphokine interleukin 2 and subsequently cocultured with tumor cells derived from malignant tumor cell lines or from fresh human tumors. The cell suspensions were subsequently inoculated into(More)
  • T Dalton
  • 1987
1. Continual stimulation of frog skin epithelium and the salivary glands of the insects Calliphora and Musca with 5-hydroxytryptamine (5-HT) leads to desensitisation, i.e. the tissue fails to respond to the application of further 5-HT. 2. Incubation of desensitised frog skin and Musca salivary glands with either N-acetyl neuraminic acid or inositol(More)