• Publications
  • Influence
Follow the leader: the use of leader peptides to guide natural product biosynthesis.
The avalanche of genomic information in the past decade has revealed that natural product biosynthesis using the ribosomal machinery is much more widespread than originally anticipated. Nearly all ofExpand
  • 292
  • 7
Sublancin is not a lantibiotic but an S-linked glycopeptide
Sublancin is shown to be an S-linked glycopeptide containing a glucose attached to a Cys residue, establishing a new post-translational modification. The activity of the S-glycosyl transferase wasExpand
  • 148
  • 7
  • PDF
Insights into the Mode of Action of the Two-Peptide Lantibiotic Haloduracin
Haloduracin, a recently discovered two-peptide lantibiotic composed of the post-translationally modified peptides Halα and Halβ, is shown to have high potency against a range of Gram-positiveExpand
  • 90
  • 6
The glycosyltransferase involved in thurandacin biosynthesis catalyzes both O- and S-glycosylation.
The S-glycosyltransferase SunS is a recently discovered enzyme that selectively catalyzes the conjugation of carbohydrates to the cysteine thiol of proteins. This study reports the discovery of aExpand
  • 40
  • 2
Haloduracin α Binds the Peptidoglycan Precursor Lipid II with 2:1 Stoichiometry
The two-peptide lantibiotic haloduracin is composed of two post-translationally modified polycyclic peptides that synergistically act on Gram-positive bacteria. We show here that Halα inhibits theExpand
  • 38
  • 2
In Vitro Mutasynthesis of Lantibiotic Analogues Containing Nonproteinogenic Amino Acids
Lantibiotics are ribosomally synthesized and post-translationally modified peptide antibiotics containing the characteristic thioether cross-links lanthionine and methyllanthionine. To date, noExpand
  • 78
  • 1
Mode of action and structure–activity relationship studies of geobacillin I
Lanthipeptides are lanthionine- and methyllanthionine- containing peptides that are ribosomally-synthesized and post-translationally modified.1 Lanthipeptides that possess antimicrobial activity areExpand
  • 20
  • 1
An Engineered Lantibiotic Synthetase That Does Not Require a Leader Peptide on Its Substrate
Ribosomally synthesized and post-translationally modified peptides are a rapidly expanding class of natural products. They are typically biosynthesized by modification of a C-terminal segment of theExpand
  • 51
Non-proteinogenic Amino Acids in Lacticin 481 Analogues Result in More Potent Inhibition of Peptidoglycan Transglycosylation
Lantibiotics are ribosomally synthesized and post-translationally modified peptide natural products that contain the thioether structures lanthionine and methyllanthionine and exert potentExpand
  • 24
NMR Structure of the S-Linked Glycopeptide Sublancin 168
Sublancin 168 is a member of a small group of glycosylated antimicrobial peptides known as glycocins. The solution structure of sublancin 168, a 37-amino-acid peptide produced by Bacillus subtilisExpand
  • 28