Trent H. Smith

Learn More
A requisite step in reovirus infection of the murine intestine is proteolysis of outer-capsid proteins to yield infectious subvirion particles (ISVPs). When converted to ISVPs by intestinal proteases, virions of reovirus strain type 3 Dearing (T3D) lose 90% of their original infectivity due to cleavage of viral attachment protein s1. In an analysis of eight(More)
A circular permuted variant of the potent human immunodeficiency virus (HIV)-inactivating protein cyanovirin-N (CV-N) was constructed. New N- and C-termini were introduced into an exposed helical loop, and the original termini were linked using residues of the original loop. Since the three-dimensional structure of wild-type cyanovirin-N is a pseudodimer,(More)
The antibacterial activity of ten N-alkylated derivatives of daunorubicin and adriamycin as well as of 5-iminodaunorubicin has been tested by using Bacillus subtilis 170, Escherichia coli B, and Proteus mirabilis VI and their stable protoplast type L-forms in an agar diffusion test. Eight of the substances showed similar activities against B. subtilis and(More)
This paper presents the analysis and design of two decoupled, concentric and coplanar PCB coils. Decoupled coils could be used as two independent receivers sensing the same field and not interfering with each other. In order to nullify the mutual inductance, one of the coils is split into two segments and the segments are wound in different directions,(More)
Although it is a widely held belief that racial bias exists in law enforcement, the courts have found it difficult to prove that an officer singled out a suspect because of race. This paper models the interaction between motorists and police and develops an alternative empirical approach to measure racial bias. In previous work, perfect observability by(More)
Post-transcriptional gene silencing (PTGS) is a fundamental regulatory mechanism operating in diverse types of organisms, but the cellular components of the gene silencing machinery and the regulation of the process are not understood. Recent findings that cytoplasmically replicating RNA viruses act as both targets and inducers of PTGS has led to the idea(More)
  • 1