Travis I. Thompson

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OBJECTIVE To determine whether phenotypic differences exist among individuals with Prader-Willi syndrome with either type I or type II deletions of chromosome 15 or maternal disomy 15 leading to a better understanding of cause and pathophysiology of this classical genetic syndrome. METHODS We analyzed clinical, anthropometric, and behavioral data in 12(More)
OBJECTIVE Prader-Willi syndrome (PWS) is a genetic disorder associated with developmental delay, obesity, and obsessive behavior related to food consumption. The most striking symptom of PWS is hyperphagia; as such, PWS may provide important insights into factors leading to overeating and obesity in the general population. We used functional magnetic(More)
PURPOSE The mean length of children's utterances is a valuable estimate of their early language acquisition. The available normative data lack documentation of language and nonverbal intelligence levels of the samples. This study reports age-referenced mean length of utterance (MLU) data from children with specific language impairment (SLI) and children(More)
1. A fixed interval-fixed ratio chain of behavior was maintained for periods as long as 6 months by intravenously administered morphine. 2. The morphine reinforced FI-FR chain was found to be a sensitive and reliable index of motivational changes induced by drug deprivation, nalorphine antagonism and pretreatment with morphine. 3. Profound behavioral(More)
Dramatic increases in childhood obesity necessitate a more complete understanding of neural mechanisms of hunger and satiation in pediatric populations. In this study, normal weight children and adolescents underwent functional magnetic resonance imaging (fMRI) scanning before and after eating a meal. Participants showed increased activation to visual food(More)
The current study demonstrates the ability of neuropeptide Y (NPY) to increase break points under a progressive ratio 1 (PR1) reinforcement schedule. An initial response resulted in delivery of a food reinforcer (45 mg pellet) under the PR1, and an additional response was required foreach successive reinforcer. The break point, the number of responses(More)
This paper proposes that an organism's integrated repertoire of operant behavior has the status of a biological system, similar to other biological systems, like the nervous, cardiovascular, or immune systems. Evidence from a number of sources indicates that the distinctions between biological and behavioral events is often misleading, engendering(More)
Rats having prior experience with ethanol drinking were subjected to geometrically increasing fixed-ratio (FR) schedules of ethanol reinforcement (8% W/V). The rats were tested first food deprived and then food satiated. Each third day ethanol was the reinforcer (0.25 ml/reinforcement), while on other days water, which served as the vehicle control, was(More)