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Thrombin has been found in neuritic plaques in Alzheimer's disease (AD). Also, traumatic brain injury, where neurons are exposed to high thrombin levels, is associated with an increased incidence of AD. Our objective was to determine the effects of thrombin administered in vivo on cognitive function and neuropathology. Rats were trained using a radial(More)
BACKGROUND Eosinophilic pneumonia (EP) has been noted in association with daptomycin use. The product labelling was recently updated to include EP in the Warnings and Precautions and Post-Marketing Experience sections. OBJECTIVE The objective of this study was to analyse adverse event (AE) reports submitted to the US FDA as well as published cases to(More)
PURPOSE The goal of this study is to summarize trends in rates of adverse events attributable to acetaminophen use, including hepatotoxicity and mortality. METHODS A comprehensive analysis of data from three national surveillance systems estimated rates of acetaminophen-related events identified in different settings, including calls to poison centers(More)
In this paper, we propose a formal approach for translating OODB queries to equivalent relational queries. The translation is accomplished through the use of the relational predicate graphs and the OODB predicate graphs. One advantage of using such a graph-based approach is that we can achieve bi-directional translation between relational queries and OODB(More)
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