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ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia.
- L. Rassenti, L. Huynh, +11 authors T. Kipps
- The New England journal of medicine
- 26 August 2004
BACKGROUND The course of chronic lymphocytic leukemia (CLL) is variable. In aggressive disease, the CLL cells usually express an unmutated immunoglobulin heavy-chain variable-region gene (IgV(H)) and… Expand
Expression of T Cell Co-Stimulator (ICOS) and Its Ligand and Disease Progression in B-Cell Chronic Lymphocytic Leukemia.
The interaction between T-cell costimulator, ICOS, and its ligand (ICOSL) expressed on B cells plays an important role in intercellular cognate interactions leading to lymphocyte activation. We found… Expand