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OX40 is a potent costimulatory receptor that can potentiate T-cell receptor signaling on the surface of T lymphocytes, leading to their activation by a specifically recognized antigen. In particular, OX40 engagement by ligands present on dendritic cells dramatically increases the proliferation, effector function, and survival of T cells. Preclinical studies(More)
T he initiative taken by the PRIDE investigators is to be commended and fully supported (1). They correctly identify gaps in the knowledge of how to manage inpatient dysglycemia, in particular hyperglycemia. However, as discussed recently by one of us, while there is plenty of evidence to show that hyperglycemia is associated with poor outcomes in(More)
OX40 is a potent costimulatory receptor that can potentiate T-cell receptor signaling on the surface of T lymphocytes, leading to their activation by a specifically recognized antigen. In particular, OX40 engagement by ligands present on dendritic cells dramatically increases the proliferation, effector function, and survival of T cells. Preclinical studies(More)
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