• Publications
  • Influence

Claim Your Author Page
Ensure your research is discoverable on Semantic Scholar. Claiming your author page allows you to personalize the information displayed and manage publications (all current information on this profile has been aggregated automatically from publisher and metadata sources).
  • Keith Biggadike, Randy K. Bledsoe, +12 authors Shawn P. Williams
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2009 (First Publication: 27 October 2009)
  • Crystallography and computer modeling have been used to exploit a previously unexplored channel in the glucocorticoid receptor (GR). Highly potent, nonsteroidal indazole amides showing excellentContinue Reading
  • Christopher James GlaxoSmithKline Lunniss, Anthony W. J. Cooper, +12 authors Joanne O Wiseman
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2009 (First Publication: 1 March 2009)
  • Crystallography-driven optimisation of a lead derived from similarity searching of the GSK compound collection resulted in the discovery of a series of quinoline derivatives that were highly potentContinue Reading
  • John Liddle, Francis Louis Atkinson, +26 authors Gordon G. Weingarten
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2011 (First Publication: 1 August 2011)
  • The lead optimisation of the diaminopyrimidine carboxamide series of spleen tyrosine kinase inhibitors is described. The medicinal chemistry strategy was focused on optimising the human whole bloodContinue Reading
  • Susan Marie Westaway, Alex G S Preston, +26 authors Rabinder K Prinjha
  • Medicine, Chemistry
  • Journal of medicinal chemistry
  • 2016 (First Publication: 25 February 2016)
  • Following the discovery of cell penetrant pyridine-4-carboxylate inhibitors of the KDM4 (JMJD2) and KDM5 (JARID1) families of histone lysine demethylases (e.g., 1), further optimization led to theContinue Reading
  • Steven Philip Keeling, Ian B. Campbell, +10 authors Simon J. F. Macdonald
  • Chemistry
  • 2008 (First Publication: 1 August 2008)
  • Abstract The efficient synthesis of an α-trifluoromethyl-α-tosyloxymethyl epoxide is reported. This highly versatile building block may be reacted sequentially with two different nucleophiles toContinue Reading