Tracey Marsh

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PURPOSE This manuscript describes the current statistical methodology available for active postmarket surveillance of pre-specified safety outcomes using a prospective incident user concurrent control cohort design with existing electronic healthcare data. METHODS Motivation of the active postmarket surveillance setting is provided using the Food and Drug(More)
We recently reported that circulating apolipoprotein AII (apoAII) isoforms apoAII-ATQ/AT (C-terminal truncations of the apoAII homo-dimer) decline significantly in pancreatic cancer and thus might serve as plasma biomarkers for the early detection of this disease. We report here the development of novel enzyme-linked immunosorbent assays (ELISAs) for(More)
OBJECTIVE Our objective was to assess whether the occurrence of medically attended local reactions to intramuscularly administered vaccines varies by injection site (arm versus thigh) in children 1 to 6 years of age. METHODS This is a retrospective cohort study of children in the Vaccine Safety Datalink population from 2002 to 2009. Site of injection and(More)
We consider a complete noncompact Riemannian manifold M and give conditions on a compact submanifold K ⊂ M so that the outward normal exponential map off of the boundary of K is a diffeomorphism onto M\K. We use this to compactify M and show that pinched negative sectional curvature outside K implies M has a compactification with a well defined Hölder(More)
Three-category dual level, three-category single level, and six-category single level word lists were presented for single trial free recall to 18 normals and 18 schizophrenics in remission. Schizophrenic recall was significantly inferior to that of normals across all three lists. Normals produced more clustering than schizophrenics, but the difference was(More)
Background Blood-based biomarkers for early detection of pancreatic ductal adenocarcinoma (PDAC) are urgently needed. Current biomarkers lack high sensitivity and specificity for population screening. The gold-standard biomarker, CA 19-9, also fails to demonstrate the predictive value necessary for early detection. Methods To validate a functional(More)
OBJECTIVES Estimates of treatment effectiveness in epidemiologic studies using large observational health care databases may be biased owing to inaccurate or incomplete information on important confounders. Study methods that collect and incorporate more comprehensive confounder data on a validation cohort may reduce confounding bias. STUDY DESIGN AND(More)
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