Tracey L Marsh

Learn More
PURPOSE This manuscript describes the current statistical methodology available for active postmarket surveillance of pre-specified safety outcomes using a prospective incident user concurrent control cohort design with existing electronic healthcare data. METHODS Motivation of the active postmarket surveillance setting is provided using the Food and Drug(More)
We recently reported that circulating apolipoprotein AII (apoAII) isoforms apoAII-ATQ/AT (C-terminal truncations of the apoAII homo-dimer) decline significantly in pancreatic cancer and thus might serve as plasma biomarkers for the early detection of this disease. We report here the development of novel enzyme-linked immunosorbent assays (ELISAs) for(More)
We consider a complete noncompact Riemannian man-ifold M and give conditions on a compact submanifold K ⊂ M so that the outward normal exponential map off of the boundary of K is a diffeomorphism onto M \K. We use this to compactify M and show that pinched negative sectional curvature outside K implies M has a compactification with a well defined Hölder(More)
BACKGROUND Microsimulation models synthesize evidence about disease processes and interventions, providing a method for predicting long-term benefits and harms of prevention, screening, and treatment strategies. Because models often require assumptions about unobservable processes, assessing a model's predictive accuracy is important. METHODS We validated(More)
BACKGROUND The aim of the study was to assess the bacterial community structures associated with endodontic infections using terminal restriction fragment length polymorphism (T-RFLP), and to investigate the correlation of whole community profiles with the manifestation of particular clinical features. METHODS Intraradicular samples were collected from 34(More)
Background Blood-based biomarkers for early detection of pancreatic ductal adenocarcinoma (PDAC) are urgently needed. Current biomarkers lack high sensitivity and specificity for population screening. The gold-standard biomarker, CA 19-9, also fails to demonstrate the predictive value necessary for early detection. Methods To validate a functional(More)
OBJECTIVES Estimates of treatment effectiveness in epidemiologic studies using large observational health care databases may be biased owing to inaccurate or incomplete information on important confounders. Study methods that collect and incorporate more comprehensive confounder data on a validation cohort may reduce confounding bias. STUDY DESIGN AND(More)
OBJECTIVE Our objective was to assess whether the occurrence of medically attended local reactions to intramuscularly administered vaccines varies by injection site (arm versus thigh) in children 1 to 6 years of age. METHODS This is a retrospective cohort study of children in the Vaccine Safety Datalink population from 2002 to 2009. Site of injection and(More)
  • 1