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OBJECTIVE Cerebrospinal fluid (CSF) neurofilament light chain (NfL) concentration is elevated in neurological disorders, including frontotemporal degeneration (FTD). We investigated the clinical correlates of elevated CSF NfL levels in FTD. METHODS CSF NfL, amyloid-β1-42 (Aβ42), tau, and phosphorylated tau concentrations were compared in 47 normal(More)
Introduction Many people associate virtual reality and computer simulations with science fiction, high-tech industries, and computer games; few associate these technologies with education. But virtual reality and computer simulations have been in use as educational tools for some time. Although they have mainly been used in applied fields such as aviation(More)
This study is drawn from a work programme aimed at developing improved medical counter measures for nerve agent poisoning. Guinea-pigs were administered pyridostigmine (5.1 microg/h) or physostigmine (4.7 microg/h) and hyoscine (1.94 microg/h) for 6 days via a subcutaneously implanted mini osmotic pump. Pyridostigmine inhibited red cell acetylcholinesterase(More)
Alzheimer's disease is the most prevalent cause of dementia and is associated with accumulation of amyloid-β peptide (Aβ), particularly the 42-amino acid Aβ1-42, in the brain. Aβ1-42 levels can be decreased by γ-secretase modulators (GSM), which are small molecules that modulate γ-secretase, an enzyme essential for Aβ production. BMS-869780 is a potent GSM(More)
BACKGROUND Elevated CSF τ is considered a biomarker of neuronal injury in newly developed Alzheimer's disease (AD) and mild cognitive impairment (MCI) criteria. However, previous studies have failed to detect alterations of τ species in other primary tauopathies. We assessed CSF τ protein abnormalities in AD, a tauopathy with prominent Aβ pathology, and(More)
Introduction Not all students are alike. Based on this knowledge, differentiated instruction applies an approach to teaching and learning so that students have multiple options for taking in information and making sense of ideas. The model of differentiated instruction requires teachers to be flexible in their approach to teaching and adjusting the(More)
Part of understanding normal and abnormal fear in children and adolescents is having knowledge of how they acquire fears and of how fears change across development. One way to examine the relative contributions of heredity and environment to the experience of fear is to study fear across cultures. The Fear Survey Schedule for Children-II (FSSC-II; Gullone,(More)
Introduction One way to help make a curriculum more supportive of students and teachers is to incorporate graphic organizers. Graphic organizers come in many types and have been widely researched for their effectiveness in improving learning outcomes for students with and without disabilities. This paper examines the research on educational applications of(More)
Introduction Many people associate virtual reality and computer simulations with science fiction, high-tech industries, and computer games; few associate these technologies with education. But virtual reality and computer simulations have been in use as educational tools for some time. Although they have mainly been used in applied fields such as aviation(More)
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