Toyomi Takahashi

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We previously reported that the transplantation of neural stem/progenitor cells (NSPCs) can contribute to the repair of injured spinal cord in adult rats and monkeys. In some cases, however, most of the transplanted cells adhered to the cavity wall and failed to migrate and integrate into the host spinal cord. In this study we focused on chondroitin sulfate(More)
We obtained seven monoclonal antibodies (mAbs) against chicken cellular prion protein (ChPrP(C)) by immunizing BALB/c mice with recombinant prion protein (rChPrP). Of the seven mAbs, two mAbs (6 and 26) could recognize rChPrP, but not ChPrP(C), in chicken brain lysate via Western blot (WB) analysis. Three C-terminal linear epitopes (AAANQTEVEM, RWWS and(More)
After single intradiscal injection of C-ABC in rabbit inter-vertebral discs, water content in the matrix of nucleus pulposus diminished clearly. After similar injection of C-ABC in sheep discs, disc inner pressure was diminished. After single intradiscal injection of C-ABC in dog inter-vertebral discs suffering disc herniation, the syndromes coming from the(More)
OBJECTIVE To determine the product-specific immunogenicity of a chemically-modified sodium hyaluronate derivative, hylan G-F 20, that is used in the treatment of osteoarthritis of the knee. METHODS Guinea pigs were subcutaneously immunized with hylan G-F 20 (Synvisc) once a week for 3 weeks. After resting, these animals received an intradermal challenge(More)
The antihypertensive peptides, Val-Pro-Pro and Ile-Pro-Pro, were successfully detected in the aorta of spontaneously hypertensive rats after orally administering these peptides by a guanidine-thiocyanate treatment to prevent proteolysis. Cy3-labeled versions of both peptides were localized in the endothelial cells of arterial vessels in the rats. The(More)
The concept of phonological weight has figured prominently in the literature on stress systems. It is generally assumed that the weight of a syllable is evaluated in terms of intra-rhyme structure: the decisive factor is the presence or absence of a (rhymal or nuclear) complement position. However, Aranda (Strehlow 1942) has a peculiar stress system that(More)
An investigation was conducted to evaluate the annual variation in potential predation impact (PPI) on larval and juvenile Pseudopleuronectes yokohamae by Crangon uritai in Hakodate Bay using predator-prey size relationships. Laboratory experiments were designed to estimate the favorable prey size of C. uritai through back-calculation of body length (BL) of(More)
In most privative approaches to melodic structure, the only phonological operations deemed possible are those involving the linking and delinking of primes. However, within an Element Theory model where no independent ATR prime is recognized, this restriction must be relaxed in order to accommodate cases of tongue root harmony. In response, we propose a(More)
The temporal variation in macrobenthos abundance was studied in Funka Bay in the periods 2001–2004 and 2007–2010. Dissolved oxygen just above the sea floor of the basin was lower and ignition loss at the level of the sea floor was higher in 2007–2010 than in 2001–2004. Macrobenthic species were categorized into three groups: long-lived species, sedental(More)
Recent clinical evidence suggests that hylan, a modified hyaluronan, and related products potentially elicit foreign body granulomatous inflammation in human soft tissue. We investigated the biocompatibility of hylan G-F 20 (Synvisc) for up to 28 days after intradermal injection in guinea pigs and intramuscular injection in rabbits. Compared to saline and(More)