Toyoki Kugimiya

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Kasabach-Merritt syndrome (KMS) is a rare and severe coagulation disorder caused by vascular malformations within or outside the liver. It is characterized by profound thrombocytopenia, microangiopathic hemolytic anemia, and consumption coagulopathy. We successfully managed the anesthesia for a giant hemangioma resection complicated with KMS using(More)
I/R injury is the main cause for hepatic dysfunction and failure after liver transplantation and liver resection. Therefore, reduction of I/R injury is the most important goal to improve the outcome of these procedures. Olprinone is a newly developed selective phosphodiesterase III inhibitor, which has been reported to ameliorate renal I/R injury in rats.(More)
It is unclear whether nitrous oxide (N2O) has a protective effect on cardiac function in vitro. In addition, little is known about the cardioprotective effect of anesthesia administered during hypoxia or ischemia. We therefore studied the cardioprotective effects of N2O and sevoflurane administered before or during hypoxia in isolated rat hearts. Rat hearts(More)
BACKGROUND We compared the effects of nitrous oxide (N2O) plus isoflurane with equianesthetic isoflurane alone on the L-type calcium current (I(Ca,L)), and also investigated their modulation of beta-adrenoceptor stimulation. METHODS I(Ca,L) was recorded from enzymatically isolated rabbit ventricular myocytes using the whole-cell patch clamp technique.(More)
infection. He underwent shunt removal and cerebral ventricle drainage. Aspiration after vomiting caused by increased intracranial pressure was confirmed. Sivelestat administration was initiated 2 h after the aspiration. As the patient was a child, a lower dose, 0.1 mg·kg−1·h−1, of sivelestat was administered, with the same antibiotic as that used in case 1.(More)
We report a case of amniotic fluid embolism (AFE) after cesarean section (C/S). A 35-year-old primigravida with placenta previa and myoma underwent C/S because of nonreassuring fetal status caused by medical induction of labor. C/S was performed smoothly under general anesthesia and the baby had no problems. Immediately after the end of C/S, she went into(More)
Post-operative pulmonary complications such as systemic inflammatory response syndrome (SIRS), acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are strongly associated with morbidity and mortality after esophagectomy. Post-operative administration of sivelestat sodium hydrate (sivelestat), a selective inhibitor of neutrophil elastase(More)
Waardenburg's syndrome consists of characteristic facial deformities, pigmentation anomalies, and congenital deafness [1]. Recently, a pathogenetic association between Hirschsprung's disease and Waardenburg's syndrome has been hypothesized [2-4]. Although affected patients require surgical treatment, very little has been published about the anesthetic(More)
Some mutant hemoglobin (Hb) variants are found with lowered O2 affinity. Low oxygen affinity is reported to increase the O2 availability in peripheral tissues (Kunert et al. [1996] Microvasc. Res. 52:58-68). In the present study, we used a mouse model carrying two low-affinity Hb variants, Titusville and Presbyterian, to evaluate the chronic in vivo(More)
BACKGROUND The purpose of this study was to examine whether nitrous oxide increases the inflammatory reaction in the airway in patients undergoing minor surgery. METHODS Twenty patients were divided into two groups at random. The patients were anesthetized by either sevoflurane with air (Group A: n=10) or sevoflurane with nitrous oxide (Group G: n=10). In(More)