Tove Lind-Landström

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BACKGROUND Glioblastoma (GBM) is the most common primary malignant human brain tumor with a poor prognosis. The diagnosis of GBM is based on histological features, however, few studies have evaluated their prognostic relevance in light of the latest WHO classification of 2007. AIM In this study we have evaluated the prognostic value of several clinical(More)
AIMS The limitations of the current WHO classification of astrocytomas call for a sustained effort to improve diagnostic and prognostic accuracy. The relationship between tumour growth and clinical outcome suggests that proliferative activity should be examined. The objective of this study was to evaluate the diagnostic and prognostic value of the(More)
The histopathological diagnosis of diffuse astrocytoma is challenging. As the WHO classification system is based on subjective assessments, the prognosis for the individual patient is somewhat uncertain. The aim of this study was therefore to investigate the prognostic value of various histological features, Ki-67/MIB-1 labeling index (LI), and clinical(More)
BACKGROUND The WHO classification system for astrocytomas is not considered optimal, mainly because of the subjective assessment of the histopathological features. Few prognostic variables have been found that stratify the risk of clinical progression in patients with grade II astrocytoma. For that reason there is a continuous search for biomarkers that can(More)
Due to the heterogeneous histopathology of diffuse astrocytomas we wanted to investigate the frequency of various histological features in grade II tumours. Herein we present the results of a microscopical examination and revision of 109 consecutively operated grade II tumours. The most frequent subtype was fibrillary astrocytoma (87%), whereas the(More)
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