Tou Pin Chang

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Current techniques for assessing the adequacy of tumour excision during breast conserving surgery do not provide real-time direct cytopathological assessment of the internal cavity walls within the breast. This study investigates the ability of probe-based confocal laser endomicroscopy (pCLE), an emerging imaging tool, to image the morphology of neoplastic(More)
BACKGROUND Robotic surgery offers technological solutions to current challenges of minimal access surgery, particularly for delicate and dexterous procedures within spatially constrained operative workspaces in children. The first robotic surgical procedure in a child was reported in April 2001. This review aims to examine the literature for global case(More)
New optical biopsy methods such as confocal endomicroscopy represent a promising tool for breast conserving surgery, allowing real-time assessment of tumor margins. However, it remains difficult to scan over a large surface area because of the small field-of-view. This paper presents a novel robotic instrument to perform automated scanning with a fiber(More)
Probe-based confocal laser endomicroscopy (pCLE) provides high resolution imaging of tissue in vivo. Maintaining a steady contact between target tissue and pCLE probe tip is important for image consistency. In this paper, a new prototype hand-held instrument for in vivo pCLE during Minimally Invasive Surgery (MIS) is presented. The proposed instrument(More)
Endocytoscopy is an optical biopsy technique which uses a miniaturized camera to capture white light microscopy images through an endoscope. We have developed an alternative design that instead relays images to an external camera via a coherent fiber bundle. In this paper we characterize the device and demonstrate microscopy of porcine tissue ex vivo. One(More)
Recent work on probe-based confocal endomicroscopy has demonstrated its potential role for real-time assessment of tumour margins during breast conserving surgery. However, endomicroscope probes tend to have a very small field-of-view, making surveillance of large areas of tissue difficult, and limiting practical clinical deployment. In this paper, a new(More)
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