Toshiyuki Kimura

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Propionic acidemia (PA) is an inborn error of organic acid metabolism caused by a deficiency of propionyl-CoA carboxylase. This enzyme is composed of two non-identical subunits, alpha and beta, which are encoded by the PCCA and PCCB genes, respectively. An enzyme deficiency can result from mutations in either PCCA or PCCB. To elucidate the mutation spectrum(More)
BACKGROUND Previously published evidence on ischemic mitral regurgitation (IMR) and its adverse prognosis after myocardial infarction has been based on the severity of IMR in the subacute or chronic period of myocardial infarction. However, the state of IMR can vary from the early stage to the chronic stage as a result of various responses of myocardium(More)
Upshaw-Schulman syndrome (USS) is caused by a congenital deficit in ADAMTS13 activity owing to genetic mutations. USS is characterized by severe neonatal jaundice with a negative Coombs test and repeated childhood episodes of thrombocytopenia reversible by fresh frozen plasma (FFP) infusions. We present two patients with USS, both of whom underwent exchange(More)
Dear Editor, An 87-year-old woman was admitted for 5 weeks continued fever, general fatigue, and decreased consciousness level. Neither enlargement of surface lymph nodes (LN) nor skin lesions were present. Laboratory findings revealed WBC 820/μl, hemoglobin 7.8 g/dl, platelet 3.0×10/μl, lactic dehydrogenase 395 IU/l (normal 106–211), C-reactive protein 7.2(More)
We performed laparoscopic wedge resection to treat gastric perforation that occurred as a complication of endoscopic mucosal resection (EMR) in a 53-year-old man. We believe this is an appropriate procedure to treat gastric perforation after EMR for early gastric cancer because it is safe and minimally invasive, and faster recovery can be expected than(More)
BACKGROUND Although paclitaxel-coated balloon (PCB) angioplasty is an effective procedure for in-stent restenosis (ISR) after coronary stenting, recurrent ISR after PCB angioplasty still occurs. The aim of this study was to evaluate the predictors of recurrent ISR after PCB angioplasty for ISR.Methods and Results:A total of 157 ISR lesions treated with PCB(More)
PURPOSE To evaluate the clinical implications of additional pedal artery angioplasty (PAA) for patients with critical limb ischemia (CLI). METHODS Twenty-nine patients (mean age 77.8±8.6 years; 21 men) with CLI (32 limbs) presenting with de novo infrapopliteal and pedal artery (Kawarada type 2/3) disease were reviewed. The need for PAA was based on the(More)
A purpose of this article is to describe a breakthrough technique for occlusive superficial femoral artery (SFA) recanalization: multi-site access and sheaths insertion (MUSASHI) technique. Trans-collateral retrograde approach (TCA) for SFA cannot become popular because it needs conventional (crossover or ipsilateral) approach, which might not be suitable(More)