Toshiyuki Bohgaki

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Macrolide antibiotics (Macs) such as erythromycin and clarithromycin (CAM) have anti-inflammatory effects in addition to antibacterial activity. Using these anti-inf lammatory effects , Macs have successful treated pathologies such as diffuse panbron-chiolitis and sinusitis. Similarly, several recent studies have described the successful treatment of(More)
Pulmonary arterial hypertension (PAH) associated with systemic lupus erythematosus (SLE) or mixed connective tissue disease (MTCD), in contrast to other types of PAH, may respond to immunosuppressive therapy. Most PAH cases with an immunosuppressant response were in the early stages of the disease (WHO functional class III or less). The present case was a(More)
Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder characterized by high fever, arthralgia, transient rash, hepatosplenomegaly, lymphadenopathy, liver dysfunction and leukocytosis. The diagnosis of AOSD is conferred based on clinical f indings after elimination of other causes. The mainstay of treatment is glucocorticoids and/or(More)
Anticardiolipin antibodies (aCL-IgG/IgM) and anti-β2-glycoprotein I antibodies (aβ2GPI-IgG/IgM) are laboratory tests included in the current classification criteria for definite antiphospholipid syndrome (APS). However, not all of these assays have been commercially available in Japan. We investigated the efficacy of aCL-IgG/IgM and aβ2GPI-IgG/IgM assays(More)
The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis Abstract Objective. Interstitial lung diseases (ILDs) complicated with PM or DM are frequently aggressive and refractory to treatment. Recently some reports have suggested the potential benefit of tacrolimus for severe ILD complicated with(More)
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