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  • Teruyasu Mizoguchi, Katsumasa Irie, +4 authors Kazuo Shinozaki
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1996 (First Publication: 23 January 1996)
  • We describe here the cloning and characterization of a cDNA encoding a protein kinase that has high sequence homology to members of the mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKKExpand
  • Kinnosuke Yahiro, Takuro Niidome, +7 authors Toshiya Hirayama
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 1999 (First Publication: 17 December 1999)
  • Helicobacter pylori, a Gram-negative gastric bacterium, secretes VacA, a cytotoxin that causes vacuolar degeneration of susceptible cells. Velocity sedimentation analysis showed that treatment ofExpand
  • Sumiko Kiryu-Seo, Masayuki Sasaki, +5 authors Hirosi Kiyama
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2000 (First Publication: 11 April 2000)
  • We isolated a membrane-bound metallopeptidase, DINE (damage-induced neuronal endopeptidase), by differential display PCR using rat normal and axotomized hypoglossal nuclei. The most marked propertiesExpand
  • Kazuyuki Yokoyama, Hideaki Higashi, +8 authors Masanori Hatakeyama
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2005 (First Publication: 5 July 2005)
  • Chronic infection with cagA-positive Helicobacter pylori is associated with the development of atrophic gastritis, peptic ulcers, and gastric adenocarcinoma. The cagA gene product CagA is injectedExpand
  • Eiki Yamasaki, Akihiro Wada, +7 authors Toshiya Hirayama
  • Medicine, Biology
  • Journal of Biological Chemistry
  • 2006 (First Publication: 21 April 2006)
  • Helicobacter pylori vacuolating cytotoxin, VacA, which causes vacuolation of gastric epithelial cells and other types of cultured cells, is known to stimulate apoptosis via a mitochondria-dependentExpand