Toshio Yamauchi

Shinichi Kogure3
Masaomi Kitayama3
Mitsuhiro Makino2
Kiyoshi Takasuna2
3Shinichi Kogure
3Masaomi Kitayama
2Mitsuhiro Makino
2Kiyoshi Takasuna
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  • Toshio Iwase, Naofumi Kajimura, Makoto Uchiyama, Takashi Ebisawa, Kimio Yoshimura, Yuichi Kamei +19 others
  • 2002
We tested whether the human Clock (hClock) gene, one of the essential components of the circadian oscillator, is implicated in the vulnerability to delayed sleep phase syndrome (DSPS) and non-24-hour sleep-wake syndrome (N-24). Screening in the entire coding region of the hClock gene with PCR amplification revealed three polymorphisms, of which two(More)
Trazodone is an effective antidepressant drug with a broad therapeutic spectrum, including anxiolytic efficacy. Although trazodone is usually referred to as a serotonin (5-HT) reuptake inhibitor, this pharmacological effect appears to be too weak to fully account for its clinical effectiveness. The present study aimed to elucidate the agonist properties of(More)
Nefiracetam is a novel pyrrolidone-type nootropic agent, and it has been reported to possess a potential for antiepileptic therapy as well as cognition-enhancing effects. We investigated the anticonvulsant and neuroprotective effects of nefiracetam in kainic acid-induced seizures of rats, compared with levetiracetam and standard antiepileptic drugs.(More)
We studied the extracellular effects of cesium chloride (CsCl), a blocker of the hyperpolarization-activated cationic current (I(h)), on the hippocampal theta wave in pentobarbital-anesthetized rabbits. We recorded spontaneous field potentials at the hippocampal CA1 region before and at three time periods after CsCl or saline injections. We found that CsCl(More)
This paper describes the development of an estimator of perceptual femininity (PF) of an input utterance using speaker recognition techniques. The estimator was designed for its clinical use and the target speakers are Gender Identity Disorder (GID) clients, especially MtF (Male to Female) transsexuals. The voice therapy for MtFs is composed of three kinds(More)
  • Yutaka Kitano, Chika Komiyama, Mitsuhiro Makino, Yoshio Kasai, Kiyoshi Takasuna, Masakazu Kinoshita +4 others
  • 2005
PURPOSE Nefiracetam (NEF) is a novel pyrrolidonetype nootropic agent, and it has been reported to possess various pharmacologic effects as well as cognition-enhancing effects. The present study focused on the effects of NEF in amygdala-kindled seizures and its potential for antiepileptic therapy. METHODS Effects of NEF on fully amygdala-kindled seizures(More)
The purpose of this study was to explore differences in mood profile evaluation between raters with different backgrounds. Special emphasis was placed on expertise factor, influence of mood categories, and patient heterogeneity in a clinical setting. We administered Profile of Mood Scale (POMS) to patients' families, residents, and experienced psychiatrists(More)
gamma-Hydroxybutyric acid is a naturally occurring substance that may act as a neurotransmitter or neuromodulator to elicit several biological effects. Although the existence of a specific gamma-hydroxybutyric acid receptor has been postulated, the receptor protein itself has not been cloned yet. The current study was designed to elucidate whether(More)
PURPOSE The h current (Ih) is an inwardly mixed cationic conductance activated by membrane hyperpolarization and distributed predominantly in the apical dendrites of hippocampal pyramidal neurons. To verify a hypothesis that an anomalous hyperpolarization generates an abnormal excitation by way of Ih channels, we examined the effects of Ih blockers (CsCl(More)
PURPOSE Alternate-site kindling (AK), which has been known to induce so-called kindling antagonism, was performed in the bilateral hippocampi to reveal neural mechanisms underlying hippocampal kindling. METHODS Ten adult rabbits were used. Daily kindling stimulation consisted of a 1- s train of 50 pulses (pulse duration, 1 ms) of 80 to 200 microA(More)
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