Toshio Sugahara

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To analyze the lip movement of patients with cleft lip and palate in detail, we developed a novel technique to produce a range image from a video-based motion capture system, and a unique technique to analyze lip movements in detail three-dimensionally. The accuracy of the range image obtained from the present system was investigated using a positioning(More)
The appearance of the nostril in cleft lip patients is very important in the subjective assessment of naso-labial forms and patient satisfaction. To improve the outcome of plastic surgery, a computer aided diagnostic system was developed. Facial forms were measured with a three-dimensional optical scanner (Ogis Range Finder RFX-IV) XYZ coordinates (256x240)(More)
Background: The chondrosarcoma-derived HCS-2/8 has been known to be an excellent model of human articular chondrocytes. By mimicking the arthritic conditions through the treatment of HCS-2/8 cells with cytokines, we estimated the gene expression response of ccn1 and ccn2 during the course of joint inflammation in vitro.
To quantify the shape of cleft lip noses and to evaluate the outcome following rhinoplasty objectively, a three-dimensional measuring system for the nasal shape was developed using a contact-type measuring apparatus. In this system, the surface data for a face could be obtained accurately, and facial landmarks could be identified semiautomatically. A new(More)
OBJECTIVE To evaluate the motion of the face and jaw of patients with cleft lip and palate, facial palsy, and in patients after reconstruction, a motion-analyzing system was developed. The aim of this article was to investigate the accuracy of this system and the possibility of clinical application. METHODS Markers of 1 to 2 mm were placed on the face,(More)
OBJECTIVES The aim of the present study was to determine whether there are dialectal and gender-related differences in nasalance scores for normal Japanese speakers. MATERIALS Sixty-eight volunteers consisting of 31 males (age 23.8+/-2.0) and 37 females (age 23.2+/-2.5) were included in this study. They had no diseases affecting speech, and lived in the(More)
A three-dimensional measuring system was developed to analyze changes in palatal forms of UCLP infants. This system quantified the change of the curved surface on a palate by automatically superimposing two wireframe models obtained from casts at different stages of growth. It also analyzed the curvature of the palatal surface. This system was used to study(More)
Connective tissue growth factor (CTGF/CCN2) is a potent angiogenic factor. In this report, we describe for the first time that vascular endothelial growth factor (VEGF)-mediated induction of the ctgf/ccn2 gene was a post-transcriptional event that was inhibited by a novel angiogenic inhibitor, DN-9693, in human umbilical vein endothelial cells. Steady-state(More)
The palatal forms in 20 infants with a complete unilateral cleft lip, and palate (12 with a Hotz palate and 8 without, selected at random) were studied from birth until 18 months of age. Using techniques developed previously, the degree of curvature in the palate and the magnitude of migration of the maxillary segments were measured three-dimensionally.(More)