Toshio Shimada

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Docosahexaenoic acid (C22:6, n-3), a major n-3 fatty acid of the brain, has been implicated in restoration and enhancement of memory-related functions. Because Alzheimer's disease impairs memory, and infusion of amyloid-beta (Abeta) peptide (1-40) into the rat cerebral ventricle reduces learning ability, we investigated the effect of dietary(More)
BACKGROUND AND OBJECTIVES Recently, significant progress has been made toward the development of optical, noninvasive medical diagnostics. The goal of this study was to evaluate elastic scatter measurements as a tool for diagnosing bladder cancer. STUDY DESIGN/MATERIALS AND METHODS In vivo measurements on 10 patients with suspected bladder cancer were(More)
Recent mobile processors are required to exhibit both low-energy consumption and high performance. To satisfy these requirements, dynamic voltage scaling (DVS) is currently employed. However, its effectiveness will be limited in the future because of shrinking the variable supply voltage range. As an alternative, we previously proposed pipeline stage(More)
In the present study, we investigated the relationship between the docosahexaenoic acid (DHA)-induced protection of learning deficit of amyloid beta(1-40)-infused Alzheimer's disease (AD) model rats and changes in synaptosomal plasma membrane fluidity of the cerebral cortex. Synaptosomal membrane lateral and rotational fluidity were measured using pyrene(More)
BACKGROUND AND PURPOSE Assessment of left atrial appendage (LAA) function with transesophageal echocardiography is useful for detecting patients at high risk for thromboembolism as a result of atrial fibrillation (AF). A recent study reported that the atrium is the main source of brain natriuretic polypeptide (BNP) in AF patients without overt heart(More)
Mast cells perform a significant role in the host defense against parasitic and some bacterial infections. Here we show that in the dog, degranulation of brain mast cells evokes hypothalamic-pituitary-adrenal responses via histamine release. A large number of mast cells were found in a circumscribed ventral region of the hypothalamus, including the pars(More)
BACKGROUND The relationship between plasma uridine levels and blood pressure (BP), and indicators of muscular purine degradation and insulin resistance (IR) has been evaluated in hypertensive (HT) patients. METHODS AND RESULTS In 36 HT patients and 10 normotensive subjects, seated BP was measured, and blood samples were drawn after overnight fast. In 18(More)
A processing element and a structure element of data flow computer SIGMA-1 for scientific computations is now operational. The elements are evaluated for several benchmark programs. For efficient execution of loop constructs, the sticky token mechanism which holds loop invariants is evaluated and exhibits a remarkable effect. From the standpoint that(More)
Efficiency in vector handling is the key to obtaining high performance in numerical programs. So far, the main defect of dataflow computers is inefficiency in vector processing. We propose structure-flow processing as a new scheme for handling data structures such as vectors in dataflow architecture. The main objective of structure-flow processing is to(More)