Toshio Ishikawa

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We created a nonclassical estrogen receptor (ER) knock-in mouse model by introducing a mutation that selectively eliminates classical ER signaling through estrogen response elements, while preserving(More)
BACKGROUND AND AIM We have developed a new rat model that mimics the natural course of diabetic nephropathy seen in type 2 diabetes. METHODS Nine days after intravenous injection of streptozotocin(More)
Interferonand TNF synergistically induce the inducible isoform of nitric oxide synthase and elicit severe cytotoxicity in pancreatic -cells. We demonstrate here that GH, the well known -cell mitogen,(More)