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  • Yusuke Ogitani, Tetsuo Aida, +13 authors Toshinori Agatsuma
  • Medicine, Biology
  • Clinical cancer research : an official journal of…
  • 2016 (First Published: 15 October 2016)
  • PURPOSE An anti-HER2 antibody-drug conjugate with a novel topoisomerase I inhibitor, DS-8201a, was generated as a new antitumor drug candidate, and its preclinical pharmacologic profile was assessed.Continue Reading
  • Yusuke Ogitani, Katsunobu Hagihara, Masataka Oitate, Hiroyuki Naito, Toshinori Agatsuma
  • Biology, Medicine
  • Cancer science
  • 2016 (First Published: 1 July 2016)
  • Antibody-drug conjugates deliver anticancer agents selectively and efficiently to tumor tissue and have significant antitumor efficacy with a wide therapeutic window. DS-8201a is a human epidermalContinue Reading
  • Tomomi Nakayama Iwata, Chiaki Ishii, Saori Ishida, Yusuke Ogitani, Teiji Wada, Toshinori Agatsuma
  • Biology, Medicine
  • Molecular cancer therapeutics
  • 2018 (First Published: 1 July 2018)
  • Trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody-drug conjugate with a topoisomerase I inhibitor exatecan derivative (DX-8951 derivative, DXd), has been reported to exert potent antitumorContinue Reading