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Biochemical networking contributes more to genetic buffering in human and mouse metabolic pathways than does gene duplication
During evolution different genes evolve at unequal rates, reflecting the varying functional constraints on phenotype. An important contributor to this variation is genetic buffering, which reducesExpand
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Gene-environment interactions reveal a homeostatic role for cholesterol metabolism during dietary folate perturbation in mice.
Dietary folate supplementation can dramatically reduce the severity and incidence of several common birth defects and adult diseases that are associated with anomalies in homocysteine and folateExpand
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Genetic and phenotypic analysis of seizure susceptibility in PL/J mice
Epilepsy is one of the most common but genetically complex neurological disorders in humans. Identifying animal models that recapitulate human epilepsies is important for pharmacological studies ofExpand
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