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Intracellular and extracellular loops of LRRC8 are essential for volume-regulated anion channel function
The volume-regulated anion channel (VRAC) is expressed ubiquitously in vertebrate cells and mediates swelling-induced release of Cl− and organic solutes. Recent studies by several laboratories haveExpand
A 30-year journey from volume-regulated anion currents to molecular structure of the LRRC8 channel
The swelling-activated anion channel VRAC has fascinated and frustrated physiologists since it was first described in 1988. Multiple laboratories have defined VRAC’s biophysical properties and haveExpand
Leucine‐rich repeat containing protein LRRC8A is essential for swelling‐activated Cl− currents and embryonic development in zebrafish
A volume‐regulated anion channel (VRAC) has been electrophysiologically characterized in innumerable mammalian cell types. VRAC is activated by cell swelling and mediates the volume regulatory effluxExpand
CLC anion channel regulatory phosphorylation and conserved signal transduction domains.
The signaling mechanisms that regulate CLC anion channels are poorly understood. Caenorhabditis elegans CLH-3b is a member of the CLC-1/2/Ka/Kb channel subfamily. CLH-3b is activated by meioticExpand
Role of CBS and Bateman Domains in Phosphorylation-Dependent Regulation of a CLC Anion Channel.
Eukaryotic CLC anion channels and transporters are homodimeric proteins composed of multiple α-helical membrane domains and large cytoplasmic C-termini containing two cystathionine-β-synthase domainsExpand
Regulatory Conformational Coupling between CLC Anion Channel Membrane and Cytoplasmic Domains.
CLC anion channels are homodimeric proteins. Each subunit is comprised of 18 α-helices designated "A-R" and an intracellular carboxy-terminus containing two cystathionine-β-synthase (CBS1 and CBS2)Expand
Hydrostatic pressure regulates tight junctions, actin cytoskeleton and transcellular ion transport.
In the epithelia and endothelia, tight junctions regulate the movement of several substances through the paracellular pathway, maintaining several gradients between apical and basal compartmentsExpand
NaCl flux between apical and basolateral side recruits claudin-1 to tight junction strands and regulates paracellular transport.
In multicellular organisms, epithelia separate and divide the internal environment maintaining appropriate conditions in each compartment. To maintain homeostasis in these compartments, claudins,Expand
Regulatory phosphorylation induces extracellular conformational changes in a CLC anion channel.
CLH-3b is a CLC-1/2/Ka/Kb channel homolog activated by meiotic cell cycle progression and cell swelling. Channel inhibition occurs by GCK-3 kinase-mediated phosphorylation of serine residues on theExpand
Caveolin-3 regulates the Volume-Regulated Anion Channel in Mouse Ventricular Cells
Caveolae are small invaginated microdomains located with a variety of signal transduction molecules on the plasma membrane. Recent reports showed that the knockout mice of a muscle-specific proteinExpand