Toshikazu Shimizu

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Insomnia is a common problem for people with chronic pain. Cortical GABAergic neurons are part of the neurobiological substrate that underlies homeostatic sleep regulation. In the present study, we confirmed that sciatic nerve ligation caused thermal hyperalgesia and tactile allodynia in mice. In this experimental model for neuropathic pain, we found an(More)
A multiplex analysis for profiling the expression of candidate genes along with epigenetic modification may lead to a better understanding of the complex machinery of neuropathic pain. In the present study, we found that partial sciatic nerve ligation most remarkably increased the expression of monocyte chemotactic protein 3 (MCP-3, known as CCL7) a total(More)
BACKGROUND Dynorphin A in the spinal cord is considered to contribute to nociceptive stimuli. However, it has not yet been determined whether activation of the spinal dynorphinergic system under nociceptive stimuli plays a role in direct acceleration of the ascending nociceptive pathway. In this study, the authors investigated the role of spinal(More)
The well-posedness (existence and uniqueness of solutions) problem and the stabilization problem of switch-driven piecewise affine (PWA) systems with 2 binary switches are addressed. First, under some assumptions, a necessary and sufficient condition for the system to be well-posed is derived. Next, based on this result, an approach to find a dynamic state(More)
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