Toshikazu Sekine

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Six lignans including a new lignan (1), beta-sitosterol glucopyranoside and phenylpropanoids were isolated from the whole plants of Balanophora abbreviata Bl. (Balanophoraceae). Their structures were determined by NMR, MS analysis and other spectroscopic methods. Lignans (1, 2 and 4) showed potent inhibitory activities on the lipopolysaccharide(More)
Invasive aspergillosis has become a serious problem in clinical practice, but the actual factor that confers virulence on the fungus has not been thoroughly elucidated. To identify and isolate the immunosuppressive substances produced by the fungus, the bioactivity of culture filtrates was assessed, and analyses of the culture filtrates were carried out.(More)
—This paper demonstrates the low-energy operation of a two-phase clocked adiabatic static CMOS logic (2PASCL) on the basis of the results obtained in the simulation of a 4-bit ripple-carry adder (RCA) and D-flipflop employing 2PASCL circuit technology. Two-phase unsymmetrical power supply clocks are introduced to increase the logic transition level. Energy(More)
— This paper proposes a novel two-phase drive adi-abatic dynamic CMOS logic circuit (2PADCL). The proposed 2PADCL uses two complementary sinusoidal power supply clocks and resembles behavior of static CMOS. As a result, the delay time of the 2PADCL is shorter than that of the conventional ADCL circuit in the second and subsequent stages. The structure of(More)
Gliotoxin, one of the mycotoxins produced by Aspergillus fumigatus, has various, potent bioactivities. However, it has not been considered to be a toxic (or virulence) factor because of its slow production. The aim of the present study was to investigate the effects of aeration on the cytotoxicity of A. fumigatus culture filtrate, and to determine the(More)
—This paper presents a new quasi adiabatic logic family that uses a pair of complementary split-level sinusoidal power supply clocks for digital low power applications such as sensors. The proposed two phase clocked adiabatic static CMOS logic (2PASCL) circuit utilizes the principle of adiabatic switching and energy recovery. By removing the diode at the(More)
This paper demonstrates the low-energy operation of a two-phase clocked adiabatic static CMOS logic (2PASCL) on the basis of the results obtained in the simulation of a 4-bit ripple-carry adder (RCA) employing 2PASCL circuit technology. Energy dissipation in the 2PASCL RCA is 71.3% lesser than that in a static CMOS RCA at transition frequencies of 10-100(More)
This paper describe the design and VLSI implementation of a multiplier using an adiabatic logic which is called a two phase drive adiabatic dynamic CMOS logic (2PADCL) circuit. Circuit operation and performance has been evaluated using a 4×4-bit 2PADCL multiplier fabricated in a 1.2 µm CMOS process. The experimental results show that the multiplier was(More)
Aspergillus fumigatus often causes serious health problems. The airway of the human body, the most common initial site of damage, is always exposed to an oxygenated condition, and the oxygen concentration may play a critical role in the virulence of A. fumigatus. In this study, oxygen content, fungal growth, the production of cytotoxic substance(s) in the(More)
Numerous articles and patents on the masking of logic gates in CMOS logic styles have been reported, however, less information is available with regards to comparing the single-rail and dual-rail on masking input logic values. This paper investigates single-rail and dual-rail logic families that have been developed by the logic designers for secure logic(More)