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Haematopoietic stem cells give rise to progeny that progressively lose self-renewal capacity and become restricted to one lineage. The points at which haematopoietic stem cell-derived progenitors commit to each of the various lineages remain mostly unknown. We have identified a clonogenic common lymphoid progenitor that can differentiate into T, B and(More)
Proinflammatory cytokines, including interleukin (IL)-1beta, are known to modulate effects of neurotoxic neurotransmitters discharged during excitation or inflammation in the central nervous system (CNS). They also regulate development of glial scars at sites of CNS injury. To elucidate a genetic predisposition of temporal lobe epilepsy with hippocampal(More)
Prion protein (PrP) is a glycoprotein constitutively expressed on the neuronal cell surface. A protease-resistant isoform of prion protein is implicated in the pathogenesis of a series of transmissible spongiform encephalopathies. We have developed a line of mice homozygous for a disrupted PrP gene in which the whole PrP-coding sequence is replaced by a(More)
The abilities of Salmonella serovars to colonize the reproductive organs of chickens and to contaminate eggs were compared. Mature laying hens were inoculated intravenously with 10(5) colony-forming units of Salmonella enteritidis, Salmonella typhimurium, Salmonella infantis, Salmonella hadar, Salmonella heidelberg, or Salmonella montevideo to cause the(More)
In this review, we focussed on gustatory transduction mechanisms in frog taste cells on the basis of our research data. The frog taste cells were stimulated with four basic taste stimuli and pure water, and the receptor potentials and currents were recorded with microelectrode and patch pipette techniques. The taste cell membrane is divided into the apical(More)
The ionic mechanism underlying the receptor potential in frog taste cells induced by sugar stimuli was studied with conventional microelectrodes by replacing the superficial and interstitial fluids of the tongue with modified solutions. The taste cell generated a depolarizing receptor potential accompanying a remarkable reduction of input resistance in(More)
Bovine haptoglobin, which has been recognized as an acute phase protein following tissue injury and inflammation, was detected as a 33 k + 20 k Dalton fraction in the sera from calves transported by road for 2 days. The sera also possessed suppressive activity on lymphocyte proliferative response to concanavalin A. A significant correlation (r = 0.57, P <(More)
Seroepidemiological and laboratory virological evidences strongly suggested that endemicity of HTLV-1 in Nagasaki Japan depends on maternal infant infections via breast milk. The most obvious way to prove this concept was an intervention study with refraining from breast-feeding by carrier mothers. Most infected babies seroconverted by the age of 12 months,(More)
The ionic mechanism of the conductance activated by acetic acid was analyzed in isolated bullfrog taste cells under whole-cell voltage-clamp. Bath-application of acetic acid (pH 3.9-4.7) induced an inward current in about 80% of the taste cells. The current occurred in external 80 mmol l-1 Ba2+ and internal 100 mmol l-1 Cs+, which completely blocked the(More)
Using single channel recordings of the patch clamp method, we found first that cation channels were present in the bullfrog taste cell membranes. These channels were widely distributed over the taste cell membrane. The conductance examined with inside-out patches was 30.7 +/- 5.7 pS (mean +/- S.D., n = 13). The permeability ratio of the cation channel to(More)