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PFA (Phalera flavescens agglutinin) lectin purified from larvae of the lobster moth (P. flavescens) shows a strong binding ability specific to the N-acetyllactosamine (Galβ1-4GlcNAc) site. We determined the genomic and cDNA sequences of the PFA gene, which consists of five exons and spans approximately 5 kb of a genomic region. Surprisingly, the amino acid… (More)
New carbocyclic c-nucleoside precursors have been synthesized in stereocontrolled manner by nonoxidative C-C bond fission (i.e., Grob fragmentation or retrograde aldol reaction) starting from Diels-Alder adducts of cyclopentadiene with 3-acetoxyacrylates or dimethyl 2-acetoxymethylenemalonate.
When full STR profiles cannot be obtained, further DNA analyses targeting single nucleotide polymorphisms (SNPs) may occasionally yield valuable information. Although the discrimination power of each SNP is relatively low, combined analysis of many SNPs can improve the personal identification ability to a level as high as that of commercial STR typing kits.… (More)
Aromatherapy and plant-based essential oils are widely used as complementary and alternative therapies for symptoms including anxiety. Furthermore, it was reportedly effective for the care of several diseases such as Alzheimer's disease and depressive illness. To investigate the pharmacological effects of essential oils, we developed an in vitro assay… (More)
Reactions of chloro(alkoxycarbonyl)methylenetriphenylphosphoranes with protected D-ribofuranoses resulted in the exclusive formation of C-beta-D-ribofuranosyl glycosides, which were converted to some C-nucleosides, such as showdomycin and pyrido-[1,2-a]pyrimidine C-nucleosides.
The photochemical reaction of 3-deazauridines was investigated with the intention of obtaining chiral beta-lactams. Irradiation of appropriately protected 3-deazauridines at greater than or equal to 300 nm gave 2-(protected D-ribofuranosyl)-3-oxo-2-azabicyclo[2.2.0]hex-5-enes as a mixture of diasteromers, which were chromatographically separable. Treatment… (More)