Toshihiko Yoshino

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Erythroblastic islands are anatomical units consisting of a central macrophage surrounded by erythroblasts. We studied the adhesion molecules involved in the formation of these structures. Central macrophages of erythroblastic islands isolated from the spleens of phlebotomized mice were clearly stained for vascular cell adhesion molecule 1 (VCAM-1). The(More)
Erythropoiesis occurs in the presence of erythropoietin (EPO) without macrophages in vitro. In hematopoietic tissues, however, erythroid cells associate closely with stromal macrophages, forming erythroblastic islands via interactions with adhesion molecules. To elucidate the role of macrophages in erythropoiesis, we selectively abrogated stromal(More)
This study explored whether load auditory stimuli could be used as functional punishing stimuli in place of electric shock. Three experiments examined the effect of a loud auditory stimulus on rats' responding maintained by a concurrent reinforcement schedule. In Experiment 1, overall response rate decreased when a concurrent 1.5 s tone presentation(More)
An optical fiber sensor is presented that allows current and voltage to be measured simultaneously by use of only one block of bismuth germanate crystal. The polarized light from the sensing crystal is split into two light beams: One beam is utilized for current measurement based on the Faraday effect, and the other one is utilized for voltage measurement(More)
To stabilize the phase-shifting Fizeau-type interferometer against environmental disturbances (namely, vibration and temperature variations), the feedback scheme that uses the current-induced frequency modulation of a laser diode (lambda = 633 nm) and the two-frequency optical heterodyne method has been investigated, with particular attention to improvement(More)
The release of digoxin and its simultaneous conversion to digoxigenin bisdigitoxoside, digoxigenin monodigitoxoside, and digoxigenin in a USP dissolution test medium were followed by high-pressure liquid chromatography. Two products, Tablets A and B, were manufactured by solvent deposition and simple blending methods, respectively. Tablet A released digoxin(More)
An orthogonal linear polarization operated ring laser with a superluminescent diode has been demonstrated to generate a tunable optical beat signal. The ring cavity contains a superluminescent diode as the optical gain medium, Faraday rotators, and a variable phase retarder (Babinet-Soleil compensator). By controlling the retarder, we changed the beat(More)
A new type of Faraday effect optical current transformer has been developed that uses a single block of square flint glass with dielectric-coated total reflection surfaces as the sensing element. Numerical calculation has shown that the coating of two dielectric layers of 45.59-nm-thick Ta2O5 and 448.35-nm-thick SiO2 films on a flint glass surface produces(More)